Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| AU565 | Senexin B | inf | 0.8184 | 0.1417 | 0.0000 | 0.8787 | 0.0100 | 0.0000 | 0.163234872 |
| SUM1315MO2 | AZD2014 | 0.001390649 | 0.0852 | 0.6690 | 6.8904 | -0.6708 | 0.1000 | 0.3997 | 0.001697935 |
| MCF7 | LY3023414 | 4.48e-05 | -0.3005 | 0.8320 | 2.0083 | -0.9593 | 0.1000 | 0.7407 | 4.7e-08 |
| Hs 578T | LY3023414 | 0.000331352 | 0.0271 | 0.6875 | 0.1184 | -0.4001 | 0.1000 | 0.8522 | 4.17e-11 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| MDA-MB-436 | LY3023414 | 4.691952741 | 0.1749 | 0.3897 | 1000.0000 | -0.3698 | 0.1033 | 0.4098 | 0.001372738 |
| HCC38 | LY3023414 | 0.003293109 | -0.0192 | 0.6632 | 57.0896 | -0.9609 | 0.1099 | 0.8238 | 3.77e-10 |
| HME1 | LY3023414 | 0.00281434 | 0.0335 | 0.6767 | 41.9336 | -1.0000 | 0.1143 | 0.9275 | 5.66e-15 |
| HCC1395 | LY3023414 | 0.006658349 | -0.1896 | 0.6194 | 2.1680 | -0.4984 | 0.1195 | 0.4950 | 0.000195378 |
| MCF7 | AZD2014 | 3.5e-06 | -0.0241 | 0.8202 | 0.0000 | -0.1837 | 0.1224 | 0.6911 | 4.19e-07 |
| SUM1315MO2 | Rucaparib | 17.80541463 | 0.2942 | 0.3317 | 1000.0000 | -0.3226 | 0.1236 | 0.3203 | 0.008018079 |
| HCC1428 | LY3023414 | 4.66e-07 | -0.7374 | 1.2208 | 0.0032 | -1.0000 | 0.1242 | 0.3630 | 0.003559188 |
| HCC1954 | Ribociclib | 66.3393103634 | 0.5260 | 0.3269 | 43.1744 | 0.0265 | 0.1268 | 0.4412 | 0.000692485845485 |
| SK-BR-3 | AZD2014 | 1.21e-05 | -0.0787 | 0.8687 | 0.0006 | -0.3127 | 0.1272 | 0.7038 | 2.48e-07 |
| SUM149PT | AZD2014 | 1.870533874 | 0.3557 | 0.3916 | 1000.0000 | -0.6285 | 0.1296 | 0.8137 | 7.57e-10 |
| HCC1954 | LY3023414 | 0.000261242275613 | -0.4250 | 0.8272 | 1.0238 | -1.0000 | 0.1328 | 0.7220 | 1.12126955498e-07 |
| T47D | LY3023414 | 0.000116934 | -0.3084 | 0.9068 | 0.4558 | -1.0000 | 0.1329 | 0.9366 | 1.11e-15 |
| MDA-MB-436 | Rucaparib | 0.828754457 | 0.1932 | 0.4025 | 792.8667 | -0.7731 | 0.1362 | 0.4480 | 0.00059396 |
| BT-549 | LY3023414 | 0.000704789836999 | -0.4244 | 0.7781 | 1.5836 | -0.9316 | 0.1363 | 0.8143 | 7.2423111952e-10 |
| HCC1937 | LY3023414 | 0.148759974 | -0.0889 | 0.4702 | 448.2987 | -1.0000 | 0.1371 | 0.5290 | 8.17e-05 |
| CAL-51 | LY3023414 | 0.012387901 | -0.1180 | 0.6129 | 29.3234 | -1.0000 | 0.1414 | 0.7984 | 2.03e-09 |
| HME1 | Rucaparib | inf | 0.7189 | 0.1295 | 1000.0000 | 0.4363 | 0.1448 | 0.3705 | 0.003075156 |
| Hs 578T | Senexin B | 2420179.078 | 0.7716 | 0.1355 | 1000.0000 | 0.3393 | 0.1457 | 0.6302 | 3.97e-06 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| MDA-MB-453 | LY3023414 | 0.000358181 | -0.6542 | 0.8640 | 0.5638 | -1.0000 | 0.1492 | 0.6094 | 7.89e-06 |