Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | AZD5363 | 2.994609539 | 0.1329 | 0.2481 | 27.0282 | -1.0000 | 0.4994 | 0.6540 | 1.73e-06 |
| T47D | AZD5363 | 0.013673243 | 0.1402 | 0.6141 | 0.0075 | 0.1295 | 0.5033 | 0.9281 | 5.11e-15 |
| SK-BR-3 | MK 1775 | 0.230887652 | -0.6053 | 0.5073 | 2.0221 | -1.0000 | 0.5063 | 0.8951 | 5.72e-13 |
| MDA-MB-231 | Rucaparib | 31.9983825044 | 0.5482 | 0.0971 | 279.5298 | -1.0000 | 0.5069 | 0.4838 | 0.000257239637118 |
| T47D | Ulixertinib | 3.528421043 | 0.1952 | 0.2003 | 28.8265 | -1.0000 | 0.5230 | 0.8600 | 2.12e-11 |
| SUM149PT | Ulixertinib | 2.037761408 | 0.1734 | 0.2350 | 4.8956 | -0.2916 | 0.5241 | 0.9161 | 3.52e-14 |
| BT-549 | MK 1775 | 0.285141860039 | -0.4630 | 0.4365 | 2.2824 | -1.0000 | 0.5282 | 0.9608 | 1.11022302463e-16 |
| CAL-85-1 | THZ1 | 0.007789492 | -0.5032 | 0.6841 | 0.0452 | -0.7693 | 0.5298 | 0.8779 | 3.85e-12 |
| HCC1419 | Senexin B | 9.413213289 | 0.3560 | 0.1373 | 74.8542 | -1.0000 | 0.5299 | 0.5673 | 2.83e-05 |
| MDA-MB-361 | AZD5363 | 0.749232388 | -0.4264 | 0.3226 | 5.9277 | -1.0000 | 0.5312 | 0.7585 | 1.93e-08 |
| HME1 | Ulixertinib | 0.212403292 | -0.0098 | 0.4485 | 0.3361 | -0.1385 | 0.5327 | 0.9448 | 2.22e-16 |
| HCC1954 | Senexin B | 211.891286993 | 0.4085 | 0.3284 | 0.0138 | 0.4972 | 0.5378 | 0.5891 | 1.48480209144e-05 |
| HCC1419 | Ribociclib | inf | 0.4859 | 0.3078 | 0.0276 | 0.5173 | 0.5408 | 0.7113 | 1.8e-07 |
| MDA-MB-468 | SHP099 | 15.69903996 | 0.5419 | 0.1218 | 54.5394 | -0.4817 | 0.5418 | 0.5522 | 4.35e-05 |
| HCC1806 | MK 1775 | 0.0128166062504 | -0.4617 | 0.8151 | 0.0380 | -0.4095 | 0.5503 | 0.9684 | 1.11022302463e-16 |
| MCF 10A | GSK2334470 | 127.2855112 | 0.8292 | 0.0271 | 886.4613 | -0.9671 | 0.5546 | 0.7883 | 3.72e-09 |
| MDA-MB-453 | AZD2014 | 0.003343931 | 0.1648 | 0.6793 | 0.0016 | 0.1731 | 0.5548 | 0.7700 | 1.05e-08 |
| CAMA-1 | THZ1 | 0.032222346 | -0.5114 | 0.4685 | 0.2234 | -1.0000 | 0.5674 | 0.9266 | 6.55e-15 |
| CAL-120 | Ulixertinib | 9.575963441 | 0.4271 | 0.1000 | 64.2469 | -1.0000 | 0.5772 | 0.9125 | 5.95e-14 |
| CAL-85-1 | THZ531 | 0.06303794 | -0.2628 | 0.4242 | 0.3186 | -0.8133 | 0.5961 | 0.6795 | 6.65e-07 |
| MDA-MB-453 | MK 1775 | 0.103540362 | -0.1845 | 0.5656 | 0.2626 | -0.3748 | 0.6010 | 0.9620 | 1.11e-16 |
| HCC1143 | MK 1775 | 0.667235616 | -0.4310 | 0.3475 | 4.0400 | -1.0000 | 0.6101 | 0.9306 | 3.33e-15 |
| MDA-MB-468 | Ulixertinib | 1.621194239 | 0.3429 | 0.2660 | 0.2539 | 0.3452 | 0.6324 | 0.9377 | 8.88e-16 |
| AU565 | BMS-265246 | 0.295937858 | -0.1432 | 0.5304 | 0.7056 | -0.3746 | 0.6436 | 0.6685 | 1.01e-06 |
| MDA-MB-453 | Senexin B | 3.773643259 | 0.1441 | 0.1970 | 20.6751 | -1.0000 | 0.6459 | 0.6523 | 1.84e-06 |