Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MCF7 | AZD5363 | 12.4103884 | 0.4782 | 0.2060 | 1.1629 | 0.3135 | 0.4165 | 0.8201 | 4.86e-10 |
| BT-20 | Ulixertinib | 11.8069404762 | 0.3655 | 0.1384 | 160.1062 | -1.0000 | 0.4214 | 0.7256 | 9.53864038866e-08 |
| SUM1315MO2 | BMS-265246 | 0.006249082 | -0.1440 | 0.8126 | 0.0152 | -0.2302 | 0.4270 | 0.8836 | 2.11e-12 |
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| HCC70 | GSK2334470 | 1.24076593852 | 0.1570 | 0.2931 | 2.9247 | -0.2245 | 0.4326 | 0.8858 | 1.66633373766e-12 |
| CAMA-1 | Ribociclib | 0.009012358 | 0.1601 | 0.6510 | 0.0058 | 0.0871 | 0.4330 | 0.8208 | 4.65e-10 |
| MDA-MB-468 | MK 1775 | 0.262235497 | -0.5155 | 0.4993 | 3.2089 | -1.0000 | 0.4387 | 0.8844 | 1.93e-12 |
| SUM159PT | GSK2334470 | 25.92061031 | 0.5981 | 0.1174 | 315.7369 | -1.0000 | 0.4395 | 0.8088 | 1.04e-09 |
| HCC1937 | Ulixertinib | 15.02907863 | 0.4534 | 0.1152 | 180.4631 | -1.0000 | 0.4420 | 0.6441 | 2.46e-06 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| SUM149PT | LY3023414 | 1.560308156 | -0.0238 | 0.2943 | 18.4015 | -1.0000 | 0.4452 | 0.8188 | 5.32e-10 |
| MCF 10A | LY3023414 | 0.157364650671 | 0.0496 | 0.4399 | 0.1188 | 0.0589 | 0.4459 | 0.9485 | 1.11022302463e-16 |
| HCC1395 | Ulixertinib | 1.871580782 | 0.1659 | 0.2498 | 4.1054 | -0.2114 | 0.4489 | 0.7753 | 7.87e-09 |
| SUM159PT | Ulixertinib | 1.943050817 | 0.1333 | 0.2476 | 22.3099 | -1.0000 | 0.4501 | 0.9582 | 1.11e-16 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| MCF7 | BMS-265246 | 0.007863864 | 0.0723 | 0.6940 | 0.0070 | 0.0264 | 0.4576 | 0.9598 | 1.11e-16 |
| BT-549 | GSK2334470 | 39.8431993112 | 0.6627 | 0.0914 | 431.7005 | -1.0000 | 0.4611 | 0.6922 | 4.01254562132e-07 |
| BT-549 | BMS-265246 | 0.000876906453272 | -0.1682 | 0.9458 | 0.0017 | -0.1811 | 0.4642 | 0.9714 | 1.11022302463e-16 |
| MCF 10A | Ulixertinib | 1.461707314 | 0.2159 | 0.2704 | 2.7171 | -0.1676 | 0.4662 | 0.9511 | 1.11e-16 |
| MCF 10A | Senexin B | 617.6674136 | 0.8672 | 0.0282 | 1000.0000 | -0.1291 | 0.4768 | 0.7287 | 8.28e-08 |
| BT-549 | Ulixertinib | 14.0227864348 | 0.4913 | 0.1080 | 138.8541 | -1.0000 | 0.4792 | 0.8946 | 6.09512440519e-13 |
| MCF7 | Ulixertinib | 3.786667089 | 0.3222 | 0.1986 | 9.6095 | -0.2846 | 0.4838 | 0.8626 | 1.69e-11 |
| MCF 10A | Rucaparib | 365.312204082 | 0.8656 | 0.0388 | 751.5036 | -0.2094 | 0.4850 | 0.5902 | 1.43637187561e-05 |
| HME1 | BMS-265246 | 0.001224504 | 0.0652 | 0.8579 | 0.0014 | -0.0301 | 0.4949 | 0.9271 | 6.11e-15 |
| CAL-120 | MK 1775 | 0.196043462 | -0.2603 | 0.4877 | 0.9132 | -0.5740 | 0.4969 | 0.9800 | 1.11e-16 |