Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HME1 | LY3023414 | 0.00281434 | 0.0335 | 0.6767 | 41.9336 | -1.0000 | 0.1143 | 0.9275 | 5.66e-15 |
| HCC70 | BMS-265246 | 0.00319357669583 | -0.1940 | 0.9108 | 0.0045 | -0.1529 | 0.7677 | 0.9705 | 1.11022302463e-16 |
| HCC38 | LY3023414 | 0.003293109 | -0.0192 | 0.6632 | 57.0896 | -0.9609 | 0.1099 | 0.8238 | 3.77e-10 |
| MDA-MB-453 | AZD2014 | 0.003343931 | 0.1648 | 0.6793 | 0.0016 | 0.1731 | 0.5548 | 0.7700 | 1.05e-08 |
| AU565 | AZD2014 | 0.003613668 | 0.0045 | 0.7508 | 0.0061 | -0.0974 | 0.3356 | 0.9277 | 5.44e-15 |
| HCC38 | BMS-265246 | 0.00394749 | -0.0214 | 0.7767 | 0.0054 | -0.0686 | 0.4043 | 0.9575 | 1.11e-16 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| HCC38 | MK 1775 | 0.004188304 | -0.4069 | 0.9360 | 0.0178 | -0.4523 | 0.4447 | 0.9813 | 1.11e-16 |
| MCF 10A | LY3023414 | 0.005085163 | -0.0482 | 0.7501 | 0.0163 | -0.2112 | 0.3018 | 0.9088 | 1e-13 |
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| BT-20 | LY3023414 | 0.00529380398207 | -0.6210 | 0.7635 | 0.9065 | -1.0000 | 0.2136 | 0.7707 | 1.01291124377e-08 |
| HCC1395 | BMS-265246 | 0.005815242 | -0.2349 | 0.7953 | 0.0151 | -0.2416 | 0.4121 | 0.9312 | 3e-15 |
| CAL-85-1 | AZD2014 | 0.006143702 | 0.1542 | 0.6519 | 0.0034 | 0.0732 | 0.2721 | 0.6523 | 1.84e-06 |
| SUM1315MO2 | BMS-265246 | 0.006249082 | -0.1440 | 0.8126 | 0.0152 | -0.2302 | 0.4270 | 0.8836 | 2.11e-12 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| HCC1395 | MK 1775 | 0.006597016 | -0.5660 | 0.8421 | 0.1385 | -0.8195 | 0.3187 | 0.9403 | 5.55e-16 |
| MDA-MB-134-VI | THZ1 | 0.006632255 | -0.4554 | 0.6285 | 0.0190 | -0.5267 | 0.6824 | 0.8938 | 6.71e-13 |
| HCC1395 | LY3023414 | 0.006658349 | -0.1896 | 0.6194 | 2.1680 | -0.4984 | 0.1195 | 0.4950 | 0.000195378 |
| CAL-85-1 | THZ1 | 0.007789492 | -0.5032 | 0.6841 | 0.0452 | -0.7693 | 0.5298 | 0.8779 | 3.85e-12 |
| MCF7 | BMS-265246 | 0.007863864 | 0.0723 | 0.6940 | 0.0070 | 0.0264 | 0.4576 | 0.9598 | 1.11e-16 |
| HCC1937 | MK 1775 | 0.008394634 | -0.1880 | 0.6919 | 0.0152 | -0.1214 | 0.3668 | 0.8610 | 1.94e-11 |
| MDA-MB-361 | THZ1 | 0.008546239 | -0.7383 | 0.6919 | 0.0322 | -0.9036 | 0.7783 | 0.9320 | 2.55e-15 |
| CAMA-1 | Ribociclib | 0.009012358 | 0.1601 | 0.6510 | 0.0058 | 0.0871 | 0.4330 | 0.8208 | 4.65e-10 |
| HCC1395 | AZD2014 | 0.010334257 | 0.1983 | 0.5546 | 0.0017 | 0.1495 | 0.1950 | 0.4827 | 0.000264203 |
| HCC1428 | THZ1 | 0.011292388 | -0.8773 | 0.6550 | 0.0212 | -0.7576 | 1.4635 | 0.8598 | 2.16e-11 |