Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | Ulixertinib | 1.871580782 | 0.1659 | 0.2498 | 4.1054 | -0.2114 | 0.4489 | 0.7753 | 7.87e-09 |
| CAL-85-1 | GSK2334470 | inf | 0.1906 | 0.2483 | 0.0000 | 0.7764 | 0.0100 | 0.0000 | 0.11208861 |
| SK-BR-3 | AZD5363 | 2.994609539 | 0.1329 | 0.2481 | 27.0282 | -1.0000 | 0.4994 | 0.6540 | 1.73e-06 |
| SUM159PT | Ulixertinib | 1.943050817 | 0.1333 | 0.2476 | 22.3099 | -1.0000 | 0.4501 | 0.9582 | 1.11e-16 |
| T47D | Alvocidib | 0.115068759 | -0.1548 | 0.2473 | 0.2275 | -0.4346 | 0.9177 | 0.9066 | 1.35e-13 |
| BT-549 | Alvocidib | 0.161331919984 | -0.4334 | 0.2463 | 0.3134 | -0.7128 | 1.3342 | 0.9894 | 1.11022302463e-16 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| HCC1143 | THZ531 | 0.129709951 | -0.2293 | 0.2435 | 0.1509 | -0.2433 | 2.6173 | 0.9825 | 1.11e-16 |
| Hs 578T | AZD5363 | 4.921732237 | 0.3377 | 0.2434 | 303.2684 | -1.0000 | 0.2666 | 0.9123 | 6.16e-14 |
| HCC1143 | RO-3306 | 1.73126532 | -0.1079 | 0.2418 | 3.9460 | -0.5002 | 0.8416 | 0.9451 | 2.22e-16 |
| HCC1419 | Alvocidib | 0.180879399 | -0.2626 | 0.2408 | 0.5478 | -0.8902 | 0.9228 | 0.9420 | 3.33e-16 |
| SUM159PT | Ribociclib | 9.362543456 | 0.3950 | 0.2403 | 1000.0000 | -0.9311 | 0.2251 | 0.8497 | 5.16e-11 |
| HCC1954 | AZD5363 | 2.96992805185 | 0.2599 | 0.2385 | 51.5317 | -1.0000 | 0.3850 | 0.8789 | 3.45068418284e-12 |
| MCF 10A | Ribociclib | 11.7857143478 | 0.4369 | 0.2382 | 1000.0000 | -0.8407 | 0.2221 | 0.8769 | 4.26025881239e-12 |
| SUM149PT | Alvocidib | 0.194050461 | -0.4382 | 0.2360 | 0.3478 | -0.7138 | 1.5198 | 0.9775 | 1.11e-16 |
| SUM149PT | Ulixertinib | 2.037761408 | 0.1734 | 0.2350 | 4.8956 | -0.2916 | 0.5241 | 0.9161 | 3.52e-14 |
| SUM159PT | Alvocidib | 0.135046848 | -0.0857 | 0.2341 | 0.1695 | -0.1659 | 1.2608 | 0.9830 | 1.11e-16 |
| HCC38 | AZD6738 | 2.069548926 | -0.2338 | 0.2316 | 6.8694 | -1.0000 | 0.9157 | 0.9405 | 4.44e-16 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| HCC1419 | AZD5363 | 51.76366593 | 0.5451 | 0.2255 | 1.6243 | 0.3603 | 0.3683 | 0.5133 | 0.000123219 |
| HCC1419 | THZ531 | 0.159567693 | -0.3116 | 0.2249 | 0.1946 | -0.3196 | 2.4891 | 0.9564 | 1.11e-16 |
| HCC1143 | Alvocidib | 0.171201738 | -0.3370 | 0.2245 | 0.2832 | -0.5220 | 1.4205 | 0.9893 | 1.11e-16 |
| AU565 | AZD5363 | 5.62582806 | 0.3226 | 0.2242 | 182.9894 | -1.0000 | 0.3155 | 0.7817 | 5.48e-09 |
| AU565 | GSK2334470 | 7.667010215 | 0.3822 | 0.2226 | 556.8242 | -1.0000 | 0.2564 | 0.7005 | 2.86e-07 |
| CAL-85-1 | RO-3306 | 6.045627864 | -0.3140 | 0.2213 | 9.4578 | -1.0000 | 2.4550 | 0.5125 | 0.000125886 |