Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | SHP099 | inf | 0.7338 | 0.0420 | 0.0000 | 0.9489 | 0.0100 | 0.0000 | 0.203508371 |
| HCC1419 | THZ1 | 0.059640487 | -0.4111 | 0.3717 | 0.0888 | -0.4101 | 1.5044 | 0.9706 | 1.11e-16 |
| HCC1419 | THZ531 | 0.159567693 | -0.3116 | 0.2249 | 0.1946 | -0.3196 | 2.4891 | 0.9564 | 1.11e-16 |
| HCC1428 | MK 1775 | 4.367124658 | -0.4009 | 0.1027 | 7.4399 | -1.0000 | 2.0621 | 0.4706 | 0.000352941 |
| HCC1428 | AZD2014 | 2.19e-05 | -0.5555 | 1.2048 | 0.0005 | -0.5838 | 0.2503 | 0.4940 | 0.000200146 |
| HCC1428 | AZD5363 | inf | 1.8797 | -0.1143 | 0.0000 | 1.0000 | 0.0100 | -0.2534 | 1.0 |
| HCC1428 | AZD6738 | inf | 0.5583 | -0.2743 | 0.0000 | 1.0000 | 0.0100 | -0.1317 | 0.820290357 |
| HCC1428 | BMS-265246 | 0.000203941 | -0.4531 | 0.9502 | 0.0775 | -0.8101 | 0.1622 | 0.3392 | 0.00563904 |
| HCC1428 | Ulixertinib | 0.227625258 | 0.1375 | 0.4320 | 0.1734 | 0.1614 | 1.4315 | 0.2319 | 0.036949884 |
| HCC1428 | Alvocidib | 0.045529066 | -0.8366 | 0.5666 | 0.1496 | -1.0000 | 0.9234 | 0.6998 | 2.94e-07 |
| HCC1428 | GSK2334470 | 0.261068206 | 0.2500 | 0.4172 | 0.2322 | 0.2218 | 5.0000 | 0.2993 | 0.01172251 |
| HCC1428 | Ribociclib | #NAME? | -0.3849 | 0.7838 | 0.0000 | 0.2963 | 0.0100 | 0.0000 | 0.210923138 |
| HCC1428 | LY3023414 | 4.66e-07 | -0.7374 | 1.2208 | 0.0032 | -1.0000 | 0.1242 | 0.3630 | 0.003559188 |
| HCC1428 | RO-3306 | 3.430055795 | -0.4441 | 0.0143 | 3.8909 | -0.2512 | 3.2292 | 0.3585 | 0.003891828 |
| HCC1428 | Rucaparib | 0.023670881 | -0.2500 | 0.7420 | 7.6534 | -1.0000 | 0.1901 | 0.2290 | 0.038773048 |
| HCC1428 | Senexin B | -inf | -0.2008 | 0.6803 | 0.0000 | 0.2756 | 0.0100 | 0.0000 | 0.123657155 |
| HCC1428 | SHP099 | inf | 0.2659 | 0.1940 | 0.0000 | 0.7961 | 0.0100 | 0.0000 | 0.260975398 |
| HCC1428 | THZ1 | 0.011292388 | -0.8773 | 0.6550 | 0.0212 | -0.7576 | 1.4635 | 0.8598 | 2.16e-11 |
| HCC1428 | THZ531 | 0.034802646 | -0.8953 | 0.6552 | 0.0565 | -0.7360 | 1.8647 | 0.7050 | 2.36e-07 |
| HCC1500 | MK 1775 | -inf | -0.9646 | ||||||
| HCC1500 | AZD2014 | 1.37e-05 | -0.9997 | 1.9963 | 0.0000 | -0.9980 | 1.4781 | 0.6747 | 8.02e-07 |
| HCC1500 | AZD5363 | -inf | 0.9937 | ||||||
| HCC1500 | AZD6738 | -inf | -0.9469 | ||||||
| HCC1500 | BMS-265246 | -inf | 0.2444 | 0.9257 | 0.0000 | 0.1272 | 0.0100 | 0.0000 | 1.0 |
| HCC1500 | Ulixertinib | -inf | 0.3396 |