Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
MDA-MB-361 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0999 0.0175 0.0000 1.0000 0.0100
HCC1806 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9460 0.0193 0.0000 0.9791 0.0100
BT-549 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9516 0.0187 0.0000 0.9793 0.0100
CAMA-1 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9375 0.0403 0.0000 0.9497 0.0100
Hs 578T 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0210 0.0119 0.0000 0.9987 0.0100
HCC1419 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9816 -0.0058 0.0000 1.0000 0.0100
PDXHCI002 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9950 0.1063 0.0000 0.9127 0.0100
MDA-MB-134-VI 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.1199 0.1894 0.0000 0.8466 0.0100
HCC1954 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.8537 0.0553 0.0000 0.9409 0.0100
HCC202 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.7899 0.0919 0.0000 0.9166 0.0100
MDA-MB-231 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0514 0.0482 0.0000 0.9659 0.0100
HCC1500 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0783 0.0024 0.0000 0.9998 0.0100
PDX1258 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0981 0.0141 0.0000 0.9940 0.0100
PDX1328 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9911 0.0513 0.0000 0.9569 0.0100
BT-20 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0460 0.0369 0.0000 0.9732 0.0100
MCF7 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0084 -0.0062 0.0000 1.0000 0.0100
SK-BR-3 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9496 0.0325 0.0000 0.9679 0.0100
BT-549 b-AP15 72
0.135351703688
 -0.3599 0.8972 0.1669 -0.3392 2.4711
BT-20 b-AP15 72
0.164472498608
 -0.6967 1.0402 0.2405 -0.6510 2.1937
HCC1500 b-AP15 72
0.166633438938
 -0.5813 0.9654 0.2171 -0.5410 2.7718
CAMA-1 b-AP15 72
0.125560211136
 -0.5018 1.0206 0.1671 -0.5285 2.5236
HCC1954 b-AP15 72
0.0709214214205
 -0.7172 1.2064 0.1119 -0.6936 1.9069
MDA-MB-361 b-AP15 72
0.109447404861
 -0.6928 1.0525 0.1830 -0.6219 1.5720
MCF7 b-AP15 72
0.3096452845
 -0.3697 0.7380 0.5354 -0.3883 1.0497
MCF 10A b-AP15 72
0.247307753993
 -0.2223 0.7451 0.2767 -0.2064 3.0780