Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | LDN57444 | 72 | 22.3408232354 | 0.2285 | 0.1807 | 104.9983 | -1.0000 | 0.7099 |
| MDA-MB-134-VI | LDN57444 | 72 | inf | 0.4981 | 0.0089 | 0.0000 | 0.9326 | 0.0100 |
| PDX1258 | LDN57444 | 72 | 3.14059414409 | 0.4353 | 0.2988 | 0.2800 | 0.4861 | 1.4815 |
| HCC1937 | LDN57444 | 72 | 17.7638889324 | 0.2980 | 0.1506 | 9.8052 | 0.2523 | 1.1822 |
| MDA-MB-231 | LDN57444 | 72 | 4.94637461912 | -0.0113 | 0.2894 | 4.9647 | -0.0024 | 1.2750 |
| PDX1328 | LDN57444 | 72 | 29.0838578196 | 0.1664 | 0.1568 | 64.9414 | -1.0000 | 1.3676 |
| HCC1419 | LDN57444 | 72 | 23.1466968338 | -0.3740 | 0.1147 | 36.5806 | -1.0000 | 2.4005 |
| HCC1806 | LDN57444 | 72 | 20.8632565992 | -0.2951 | 0.1515 | 37.1169 | -1.0000 | 1.9070 |
| Hs 578T | LDN57444 | 72 | 19.4934085155 | -0.0884 | 0.1662 | 33.0205 | -0.6495 | 1.5795 |
| HCC1500 | LDN57444 | 72 | 39.3689454794 | 0.2463 | 0.0822 | 61.7679 | -1.0000 | 2.4392 |
| BT-549 | LDN57444 | 72 | 26.3227602476 | -0.0929 | 0.1129 | 39.5696 | -0.7414 | 2.2310 |
| MCF7 | LDN57444 | 72 | 39.229352909 | 0.3803 | 0.0338 | 32.3166 | 0.3103 | 5.0000 |
| BT-20 | LDN57444 | 72 | 0.273589049961 | -0.5384 | 0.7238 | 0.4768 | -0.3750 | 1.0074 |
| T47D | LDN57444 | 72 | 5.98029149748 | -0.4896 | 0.3206 | 18.7611 | -0.9206 | 0.9133 |
| PDXHCI002 | LDN57444 | 72 | inf | 0.3570 | 0.1453 | 0.0000 | 0.8080 | 0.0100 |
| HCC202 | LDN57444 | 72 | 35.5631753073 | 0.1261 | 0.0350 | 36.2274 | -0.0485 | 5.0000 |
| CAMA-1 | LDN57444 | 72 | 2.83119526 | -0.3122 | 0.4296 | 3.1629 | -0.2963 | 4.2007 |
| HCC1428 | LDN57444 | 72 | 12.549009736 | -0.0136 | 0.2378 | 89.8320 | -1.0000 | 0.5582 |
| HCC1954 | LDN57444 | 72 | 18.837326116 | 0.0230 | 0.1849 | 56.1555 | -1.0000 | 1.0058 |
| HCC1937 | MI-2 | 72 | 1.5435411034 | -0.5588 | 0.5652 | 2.1666 | -0.5722 | 2.2498 |
| MCF 10A | MI-2 | 72 | 5.79831624395 | -0.2953 | 0.3052 | 6.4633 | -0.2594 | 3.8494 |
| MDA-MB-361 | MI-2 | 72 | 3.80487472111 | -0.7848 | 0.4779 | 4.6826 | -0.7574 | 4.4428 |
| HCC1419 | MI-2 | 72 | 0.8507722389 | -0.5904 | 0.7165 | 1.0642 | -0.5907 | 3.4840 |
| PDX1258 | MI-2 | 72 | 2.05087982373 | -0.6053 | 0.5515 | 3.4388 | -0.6650 | 1.6366 |
| MDA-MB-134-VI | MI-2 | 72 | 2.69532196317 | -0.6517 | 0.5129 | 3.6232 | -0.6592 | 2.8422 |