Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF 10A | Pevonedistat | 72 | 0.283189283641 | -0.1451 | 0.6453 | 0.3283 | -0.1036 | 1.2735 |
| MDA-MB-231 | LDN57444 | 72 | 4.94637461912 | -0.0113 | 0.2894 | 4.9647 | -0.0024 | 1.2750 |
| T47D | SJB3-019A | 72 | 0.197447266274 | -0.5628 | 0.9021 | 0.3562 | -0.5619 | 1.2767 |
| HCC1500 | Sepantronium | 72 | 0.48222369882 | -0.6675 | 0.7593 | 0.9213 | -0.6468 | 1.2822 |
| MCF7 | HY-50736 | 72 | 0.048225043242 | -0.1348 | 0.9464 | 0.0630 | -0.2053 | 1.2899 |
| MCF7 | HBX 41108 | 72 | 0.390147535667 | -0.2149 | 0.6730 | 0.5376 | -0.2563 | 1.2906 |
| HCC202 | Vialinin A | 72 | 7.85110394178 | -0.4245 | 0.2333 | 14.2814 | -0.5846 | 1.2943 |
| MDA-MB-361 | SB1-F-22 | 72 | 89.7808679432 | 0.3965 | 0.0864 | 5.1416 | 0.4877 | 1.2948 |
| CAMA-1 | HY-17541A | 72 | 7.52712235452 | -0.7494 | 0.2920 | 17.5656 | -1.0000 | 1.2964 |
| HCC1500 | Pimozide | 72 | 6.78743066265 | -0.5563 | 0.3689 | 15.8355 | -1.0000 | 1.2968 |
| PDXHCI002 | Pimozide | 72 | 3.73166784701 | -0.4762 | 0.4161 | 6.9559 | -0.6294 | 1.3085 |
| MCF7 | Pevonedistat | 72 | 0.150383057079 | -0.0374 | 0.6766 | 0.1518 | -0.0061 | 1.3103 |
| HCC202 | SJB2-043 | 72 | 0.34979801402 | -0.6438 | 0.6718 | 0.6597 | -0.6491 | 1.3117 |
| HCC202 | Spautin-1 | 72 | 29.2225686874 | 0.3956 | 0.1067 | 10.7821 | 0.3657 | 1.3182 |
| T47D | Pimozide | 72 | 7.11853496187 | -0.5532 | 0.3575 | 16.3429 | -1.0000 | 1.3219 |
| HCC1954 | HY-17541A | 72 | 4.05518549047 | -0.8364 | 0.4858 | 9.2414 | -1.0000 | 1.3338 |
| MCF7 | HY-50737A | 72 | 0.230613494355 | -0.1986 | 0.7394 | 0.3067 | -0.2336 | 1.3443 |
| HCC1419 | Vialinin A | 72 | 6.52356293031 | -0.5490 | 0.2630 | 13.1152 | -0.7812 | 1.3473 |
| PDXHCI002 | b-AP15 | 72 | 0.0451916121201 | -0.5737 | 1.1338 | 0.0762 | -0.5135 | 1.3527 |
| PDX1258 | b-AP15 | 72 | 0.186230489102 | -0.6381 | 0.9074 | 0.3277 | -0.5748 | 1.3539 |
| PDXHCI002 | HY-50737A | 72 | 11.4596842357 | -0.3785 | 0.2045 | 23.6412 | -0.8333 | 1.3544 |
| BT-20 | HY-50737A | 72 | 0.556969018793 | -0.5469 | 0.6980 | 0.9349 | -0.5102 | 1.3577 |
| HCC1419 | ML-323 | 72 | 19.6035773316 | 0.0958 | 0.1509 | 30.3213 | -0.4046 | 1.3594 |
| PDX1328 | LDN57444 | 72 | 29.0838578196 | 0.1664 | 0.1568 | 64.9414 | -1.0000 | 1.3676 |
| Hs 578T | SB1-F-22 | 72 | 48.629206693 | 0.4746 | 0.0557 | 108.1899 | -1.0000 | 1.3738 |