Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| T47D | HBX 41108 | 72 | 1.00606977934 | -0.4470 | 0.6172 | 1.2542 | -0.4170 | 2.7516 |
| CAMA-1 | HY-50736 | 72 | 0.00740329650359 | -0.4438 | 1.4260 | 0.0096 | -0.4747 | 2.5511 |
| T47D | Mitoxantrone | 72 | 5.66232793817e-05 | -0.4434 | 1.1468 | 0.0899 | -1.0000 | 0.1491 |
| MDA-MB-361 | HY-50736 | 72 | 0.608322194455 | -0.4431 | 0.6883 | 0.9920 | -0.5060 | 1.4296 |
| BT-20 | HY-50736 | 72 | 0.154452624267 | -0.4430 | 0.9442 | 0.2491 | -0.5003 | 1.4504 |
| PDX1328 | 1247825-37-1 | 72 | 22.1349466658 | -0.4424 | 0.1065 | 25.3891 | -0.4927 | 5.0000 |
| CAMA-1 | HBX19818 | 72 | 24.9121589631 | -0.4378 | 0.1232 | 36.6256 | -1.0000 | 2.8506 |
| SK-BR-3 | Vialinin A | 72 | 6.57450356831 | -0.4313 | 0.2897 | 11.2296 | -0.5685 | 1.4185 |
| Hs 578T | Degrasyn | 72 | 1.34100869906 | -0.4283 | 0.6057 | 1.6245 | -0.4514 | 3.3543 |
| PDX1258 | HBX19818 | 72 | 26.8677504629 | -0.4248 | 0.1477 | 37.8431 | -1.0000 | 3.2074 |
| HCC202 | Vialinin A | 72 | 7.85110394178 | -0.4245 | 0.2333 | 14.2814 | -0.5846 | 1.2943 |
| HCC1806 | Pimozide | 72 | 11.3348298234 | -0.4227 | 0.2230 | 12.8256 | -0.4274 | 5.0000 |
| MDA-MB-231 | b-AP15 | 72 | 0.181306358554 | -0.4204 | 0.8575 | 0.2432 | -0.3944 | 1.9790 |
| BT-549 | Pimozide | 72 | 12.900272139 | -0.4203 | 0.2457 | 17.3340 | -0.5372 | 2.4698 |
| SK-BR-3 | HY-50736 | 72 | 0.115680810144 | -0.4176 | 0.9862 | 0.1504 | -0.4466 | 2.4308 |
| MDA-MB-231 | P22077 | 72 | 14.6624018854 | -0.4168 | 0.1929 | 17.8309 | -0.4659 | 3.3658 |
| HCC1500 | Vialinin A | 72 | 6.94264500958 | -0.4158 | 0.2869 | 11.1402 | -0.5530 | 1.5750 |
| MCF7 | Trifluoperazine | 72 | 11.3097883651 | -0.4096 | 0.2127 | 13.2613 | -0.4283 | 3.8867 |
| BT-549 | Sepantronium | 72 | 0.0268606049638 | -0.4073 | 1.1453 | 0.0366 | -0.3708 | 1.7888 |
| HCC1954 | HY-50736 | 72 | 0.0820968061449 | -0.4069 | 1.1010 | 0.1207 | -0.5219 | 1.8530 |
| MDA-MB-361 | Vialinin A | 72 | 7.75271686789 | -0.4045 | 0.2275 | 8.9559 | -0.3189 | 3.4198 |
| HCC1954 | Vialinin A | 72 | 5.65032712603 | -0.4035 | 0.2903 | 9.0380 | -0.4804 | 1.4335 |
| MCF 10A | HY-17541A | 72 | 17.9688754214 | -0.3960 | 0.1869 | 23.8178 | -0.5829 | 2.7426 |
| Hs 578T | HY-50737A | 72 | 1.00080504529 | -0.3945 | 0.5891 | 1.4659 | -0.3655 | 1.4376 |
| MCF7 | SB1-F-21 | 72 | 0.615140979311 | -0.3940 | 0.6577 | 0.7749 | -0.3444 | 2.2705 |