Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1328 | 1247825-37-1 | 72 | 22.1349466658 | -0.4424 | 0.1065 | 25.3891 | -0.4927 | 5.0000 |
| HCC202 | Spautin-1 | 72 | 29.2225686874 | 0.3956 | 0.1067 | 10.7821 | 0.3657 | 1.3182 |
| CAMA-1 | ML-323 | 72 | 28.720597579 | 0.2218 | 0.1069 | 83.5494 | -1.0000 | 1.0288 |
| BT-549 | Spautin-1 | 72 | inf | 0.6348 | 0.1075 | 13.3350 | 0.5009 | 0.6856 |
| HCC202 | ML-323 | 72 | inf | 0.5409 | 0.1086 | 0.9673 | 0.7036 | 5.0000 |
| MCF 10A | HBX19818 | 72 | 32.2419133513 | -0.1889 | 0.1089 | 44.8110 | -1.0000 | 3.3374 |
| MCF 10A | GW7647 | 72 | 21.8868633466 | -0.1219 | 0.1105 | 23.6125 | -0.1775 | 4.0039 |
| HCC1428 | ML-323 | 72 | inf | 0.5825 | 0.1106 | 1.0330 | 0.6949 | 2.4444 |
| PDX1258 | Vialinin A | 72 | 13.4082942872 | -0.2326 | 0.1129 | 16.1961 | -0.2877 | 2.4064 |
| BT-549 | LDN57444 | 72 | 26.3227602476 | -0.0929 | 0.1129 | 39.5696 | -0.7414 | 2.2310 |
| Hs 578T | ML-323 | 72 | 133.678939825 | 0.6153 | 0.1131 | 2077.0523 | -1.0000 | 0.4005 |
| PDX1328 | USP7-IN-1 | 72 | inf | 0.9243 | 0.1135 | 0.0000 | 0.9000 | 0.0100 |
| HCC1419 | HBX19818 | 72 | 18.9629402973 | -0.3826 | 0.1144 | 33.7889 | -1.0000 | 1.9019 |
| HCC1419 | LDN57444 | 72 | 23.1466968338 | -0.3740 | 0.1147 | 36.5806 | -1.0000 | 2.4005 |
| PDX1258 | Spautin-1 | 72 | inf | 0.6270 | 0.1154 | 7.2635 | 0.5872 | 0.8220 |
| MCF 10A | LDN57444 | 72 | 27.0792914711 | -0.1381 | 0.1203 | 45.1952 | -1.0000 | 2.1448 |
| MDA-MB-134-VI | z-VAE(OMe)-fmk | 72 | inf | 0.9937 | 0.1205 | 0.0000 | 0.8924 | 0.0100 |
| BT-549 | HBX19818 | 72 | 28.4956034945 | -0.3396 | 0.1206 | 40.2238 | -1.0000 | 3.1871 |
| SK-BR-3 | Spautin-1 | 72 | 52.4840202993 | 0.5136 | 0.1207 | 9.4550 | 0.4402 | 1.2389 |
| MDA-MB-134-VI | STK547622 | 72 | inf | 0.6525 | 0.1207 | 0.0000 | 0.8937 | 0.0100 |
| MCF7 | ML-323 | 72 | 34.9041902184 | 0.3934 | 0.1213 | 138.0045 | -1.0000 | 0.7992 |
| CAMA-1 | HBX19818 | 72 | 24.9121589631 | -0.4378 | 0.1232 | 36.6256 | -1.0000 | 2.8506 |
| MDA-MB-134-VI | PB49673382 | 72 | 12.4536117294 | -0.0102 | 0.1233 | 11.0745 | 0.2220 | 5.0000 |
| SK-BR-3 | Doxycycline | 72 | 30.0303971358 | 0.1295 | 0.1243 | 58.5093 | -1.0000 | 1.6472 |
| PDX1258 | Doxycycline | 72 | inf | 0.6311 | 0.1246 | 0.0000 | 0.8362 | 0.0100 |