Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
BT-549 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9516 0.0187 0.0000 0.9793 0.0100
BT-549 IU1 72
inf
 0.9301 0.0193 16.1731 0.9293 3.6587
HCC1806 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 0.9460 0.0193 0.0000 0.9791 0.0100
HCC1806 STK547622 72
inf
 0.9848 0.0194 0.0000 0.9841 0.0100
BT-20 z-VAE(OMe)-fmk 72
inf
 0.9762 0.0198 0.0000 0.9890 0.0100
SK-BR-3 STK547622 72
inf
 0.9373 0.0215 0.0000 0.9814 0.0100
HCC202 STK547622 72
inf
 0.8807 0.0217 0.0000 0.9799 0.0100
PDXHCI002 STK547622 72
inf
 0.9789 0.0218 0.0000 0.9934 0.0100
SK-BR-3 GW7647 72
63.3177975853
 0.6434 0.0223 112.2791 -1.0000 1.9179
BT-20 USP7-IN-1 72
67.2869814403
 0.7451 0.0229 80.6417 -0.3763 3.0994
HCC1806 z-VAE(OMe)-fmk 72
inf
 0.9581 0.0231 0.0000 0.9783 0.0100
HCC1419 HY-17542 72
inf
 0.8046 0.0234 7.3179 0.8511 5.0000
CAMA-1 GW7647 72
51.1807184271
 0.5179 0.0238 80.0691 -0.9662 2.4039
PDX1258 HY-17542 72
inf
 0.8526 0.0249 0.0000 0.9656 0.0100
MCF7 IU1 72
inf
 0.7464 0.0252 29.2117 0.7291 5.0000
HCC1954 IU1 72
inf
 0.7969 0.0254 8.5142 0.7979 1.8182
T47D z-VAE(OMe)-fmk 72
inf
 0.9468 0.0261 0.0000 0.9749 0.0100
CAMA-1 z-VAE(OMe)-fmk 72
inf
 0.9619 0.0262 0.0000 0.9726 0.0100
CAMA-1 USP7-IN-1 72
90.407874652
 0.7005 0.0265 239.6012 -1.0000 1.1272
PDX1258 ML-323 72
inf
 0.7683 0.0266 0.0000 0.9660 0.0100
BT-549 SB1-F-22 72
inf
 0.8206 0.0279 14.6898 0.8108 2.3064
MDA-MB-361 z-VAE(OMe)-fmk 72
inf
 0.9096 0.0284 0.0000 0.9738 0.0100
HCC1806 USP7-IN-1 72
154.815652356
 0.8197 0.0286 421.1954 -1.0000 1.0977
PDX1258 STK547622 72
inf
 0.9659 0.0292 0.0000 0.9845 0.0100
PDX1328 z-VAE(OMe)-fmk 72
inf
 1.0551 0.0297 0.0000 0.9884 0.0100