Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)

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Cell Small Molecule Treatment Duration GR50 GRmax GR_AOC GEC50 GRinf hGR
BT-549 HY-17542 72
121.066157283
 0.9061 0.0081 95.3962 0.2549 2.9917
HCC1500 IU1 72
inf
 0.6977 0.0082 0.0000 0.9531 0.0100
HCC1937 IU1 72
inf
 0.8662 0.0085 0.0000 0.9831 0.0100
MCF7 Doxycycline 72
inf
 0.9910 0.0087 0.0000 0.9840 0.0100
MDA-MB-134-VI LDN57444 72
inf
 0.4981 0.0089 0.0000 0.9326 0.0100
MCF 10A HY-17542 72
122.726417103
 0.9130 0.0108 200.5533 -1.0000 2.2369
Hs 578T 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0210 0.0119 0.0000 0.9987 0.0100
MCF 10A IU1 72
inf
 0.9050 0.0119 30.9108 0.8598 1.4169
HCC1419 STK547622 72
inf
 1.0781 0.0128 0.0000 1.0000 0.0100
HCC1500 z-VAE(OMe)-fmk 72
inf
 1.1021 0.0136 0.0000 1.0000 0.0100
HCC202 SB1-F-22 72
inf
 0.5140 0.0137 13.2393 0.5091 4.4104
PDX1258 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0981 0.0141 0.0000 0.9940 0.0100
HCC1806 HY-17542 72
inf
 0.9036 0.0149 0.0000 0.9763 0.0100
MCF 10A 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
738.9217363
 0.8943 0.0150 255.4365 0.3311 1.0216
Hs 578T STK547622 72
inf
 0.9647 0.0155 0.0000 0.9968 0.0100
HCC1500 HY-17542 72
139.024096434
 0.7326 0.0159 49.2255 0.4705 2.7249
HCC1954 STK547622 72
inf
 0.8996 0.0165 0.0000 0.9826 0.0100
Hs 578T IU1 72
63.4449771188
 0.6256 0.0170 49.9183 0.2532 2.9451
MDA-MB-361 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one 72
inf
 1.0999 0.0175 0.0000 1.0000 0.0100
Hs 578T z-VAE(OMe)-fmk 72
inf
 0.9948 0.0176 0.0000 0.9832 0.0100
BT-549 USP7-IN-1 72
94.531181628
 0.8209 0.0177 166.1357 -1.0000 1.9483
HCC1428 HY-17542 72
inf
 0.7557 0.0179 0.0000 0.9697 0.0100
CAMA-1 HY-17542 72
inf
 0.8374 0.0179 0.0000 0.9681 0.0100
T47D STK547622 72
inf
 0.9428 0.0182 0.0000 0.9914 0.0100
BT-549 z-VAE(OMe)-fmk 72
inf
 0.9727 0.0182 0.0000 0.9828 0.0100