Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | HBX19818 | 72 | 26.0037277737 | -0.0518 | 0.1251 | 48.2744 | -1.0000 | 1.7758 |
| HCC1419 | SB1-F-22 | 72 | 16.9369859078 | 0.2855 | 0.1259 | 10.0959 | 0.3307 | 2.0935 |
| HCC1500 | ML-323 | 72 | 22.8896968406 | 0.1643 | 0.1263 | 77.3652 | -1.0000 | 0.9021 |
| MCF7 | Spautin-1 | 72 | 21.2766901138 | 0.4529 | 0.1281 | 6.4229 | 0.4329 | 1.6764 |
| MCF7 | SB1-F-22 | 72 | 13.3623714813 | 0.2021 | 0.1288 | 11.5010 | 0.2638 | 5.0000 |
| MCF7 | HBX19818 | 72 | 22.3259717989 | -0.2798 | 0.1315 | 35.8197 | -0.8671 | 2.1277 |
| HCC1954 | ML-323 | 72 | 85.295133896 | 0.5808 | 0.1325 | 985.9258 | -1.0000 | 0.4489 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |
| PDX1328 | PB49673382 | 72 | 15.1116355121 | -0.3801 | 0.1383 | 38.8250 | -1.0000 | 1.1643 |
| PDX1328 | Spautin-1 | 72 | 43.5833222905 | 0.4636 | 0.1399 | 310.0635 | -1.0000 | 0.5599 |
| PDXHCI002 | PB49673382 | 72 | 23.2849540906 | -0.0464 | 0.1415 | 59.6753 | -1.0000 | 1.1674 |
| MDA-MB-134-VI | Doxycycline | 72 | inf | 0.6687 | 0.1431 | 0.0000 | 0.8349 | 0.0100 |
| PDXHCI002 | LDN57444 | 72 | inf | 0.3570 | 0.1453 | 0.0000 | 0.8080 | 0.0100 |
| PDX1258 | HBX19818 | 72 | 26.8677504629 | -0.4248 | 0.1477 | 37.8431 | -1.0000 | 3.2074 |
| HCC1954 | HBX19818 | 72 | 22.5984065063 | -0.5316 | 0.1482 | 33.7162 | -1.0000 | 2.7458 |
| T47D | USP7-IN-1 | 72 | 35.2358506575 | 0.3921 | 0.1491 | 300.7608 | -1.0000 | 0.5124 |
| HCC1937 | LDN57444 | 72 | 17.7638889324 | 0.2980 | 0.1506 | 9.8052 | 0.2523 | 1.1822 |
| HCC1419 | ML-323 | 72 | 19.6035773316 | 0.0958 | 0.1509 | 30.3213 | -0.4046 | 1.3594 |
| HCC1806 | LDN57444 | 72 | 20.8632565992 | -0.2951 | 0.1515 | 37.1169 | -1.0000 | 1.9070 |
| HCC1428 | Doxycycline | 72 | inf | 0.5312 | 0.1526 | 0.0000 | 0.8018 | 0.0100 |
| MDA-MB-361 | PB49673382 | 72 | 9.80262963264 | -0.2517 | 0.1526 | 10.3320 | -0.1504 | 5.0000 |
| MDA-MB-231 | Vialinin A | 72 | 11.5071057567 | -0.1762 | 0.1553 | 14.2645 | -0.2485 | 1.8785 |
| PDX1328 | LDN57444 | 72 | 29.0838578196 | 0.1664 | 0.1568 | 64.9414 | -1.0000 | 1.3676 |
| BT-549 | 1247825-37-1 | 72 | 13.5700541273 | -0.0465 | 0.1614 | 13.9726 | -0.0577 | 3.7355 |
| BT-549 | P22077 | 72 | 15.5619099885 | -0.2638 | 0.1622 | 17.6412 | -0.2914 | 3.6612 |