Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF 10A | USP7-IN-1 | 72 | 130.869645041 | 0.7420 | 0.0432 | 404.8308 | -0.8498 | 0.8794 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |
| MDA-MB-361 | 1247825-37-1 | 72 | 13.2255127818 | -0.4648 | 0.1648 | 21.0813 | -0.7304 | 1.9314 |
| Hs 578T | MI-2 | 72 | 1.32338090995 | -0.3256 | 0.5792 | 1.5805 | -0.3890 | 3.2415 |
| PDX1258 | 1247825-37-1 | 72 | 13.2811411655 | 0.1210 | 0.0958 | 12.5137 | 0.1287 | 5.0000 |
| HCC1500 | Degrasyn | 72 | 1.3319409029 | -0.5824 | 0.5931 | 1.7551 | -0.5299 | 2.6195 |
| MCF7 | SB1-F-22 | 72 | 13.3623714813 | 0.2021 | 0.1288 | 11.5010 | 0.2638 | 5.0000 |
| Hs 578T | ML-323 | 72 | 133.678939825 | 0.6153 | 0.1131 | 2077.0523 | -1.0000 | 0.4005 |
| HCC1806 | HY-17541A | 72 | 13.4077616893 | -0.6698 | 0.2684 | 22.7925 | -1.0000 | 2.0705 |
| PDX1258 | Vialinin A | 72 | 13.4082942872 | -0.2326 | 0.1129 | 16.1961 | -0.2877 | 2.4064 |
| Hs 578T | Degrasyn | 72 | 1.34100869906 | -0.4283 | 0.6057 | 1.6245 | -0.4514 | 3.3543 |
| T47D | ML-323 | 72 | 13.4276900688 | 0.0649 | 0.2011 | 60.0348 | -0.9911 | 0.7296 |
| BT-549 | 1247825-37-1 | 72 | 13.5700541273 | -0.0465 | 0.1614 | 13.9726 | -0.0577 | 3.7355 |
| PDX1328 | HBX19818 | 72 | 13.6607133025 | -0.9490 | 0.3096 | 19.8613 | -1.0000 | 2.9355 |
| MCF 10A | Trifluoperazine | 72 | 13.7054527208 | -0.3753 | 0.2032 | 15.3336 | -0.3764 | 5.0000 |
| HCC1500 | HY-17542 | 72 | 139.024096434 | 0.7326 | 0.0159 | 49.2255 | 0.4705 | 2.7249 |
| MCF 10A | Degrasyn | 72 | 1.40857817808 | -0.1567 | 0.4917 | 1.5039 | -0.1937 | 5.0000 |
| PDX1258 | SB1-F-22 | 72 | 141.822011334 | 0.6791 | 0.0519 | 862.0159 | -1.0000 | 0.6088 |
| MDA-MB-134-VI | SB1-F-22 | 72 | 14.2678654794 | 0.3664 | 0.0349 | 10.7040 | 0.3812 | 5.0000 |
| HCC1937 | Pimozide | 72 | 14.4705530938 | -0.3172 | 0.2285 | 17.9899 | -0.4074 | 2.7377 |
| MDA-MB-231 | P22077 | 72 | 14.6624018854 | -0.4168 | 0.1929 | 17.8309 | -0.4659 | 3.3658 |
| SK-BR-3 | Degrasyn | 72 | 1.46725479038 | -0.5284 | 0.5755 | 2.0646 | -0.5400 | 2.1444 |
| PDX1328 | PB49673382 | 72 | 15.1116355121 | -0.3801 | 0.1383 | 38.8250 | -1.0000 | 1.1643 |
| HCC1500 | HBX19818 | 72 | 15.1685808671 | -0.6194 | 0.2142 | 22.6040 | -0.8501 | 2.4902 |
| HCC1937 | MI-2 | 72 | 1.5435411034 | -0.5588 | 0.5652 | 2.1666 | -0.5722 | 2.2498 |