Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1428 | SB1-F-22 | 72 | 31.0121984952 | 0.4228 | 0.0852 | 13.1557 | 0.3067 | 1.1083 |
| CAMA-1 | Vialinin A | 72 | 8.96202630369 | -0.5255 | 0.2577 | 13.2114 | -0.6248 | 2.0890 |
| HCC202 | SB1-F-22 | 72 | inf | 0.5140 | 0.0137 | 13.2393 | 0.5091 | 4.4104 |
| HCC1419 | Pimozide | 72 | 6.13162921953 | -0.7003 | 0.3602 | 13.2581 | -1.0000 | 1.4246 |
| MCF7 | Trifluoperazine | 72 | 11.3097883651 | -0.4096 | 0.2127 | 13.2613 | -0.4283 | 3.8867 |
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| BT-549 | Spautin-1 | 72 | inf | 0.6348 | 0.1075 | 13.3350 | 0.5009 | 0.6856 |
| CAMA-1 | 1247825-37-1 | 72 | 12.5263467336 | -0.2434 | 0.1646 | 13.4850 | -0.2229 | 5.0000 |
| HCC1806 | P22077 | 72 | 10.1999122294 | -0.4514 | 0.2415 | 13.5370 | -0.5064 | 2.4715 |
| PDX1258 | HY-17541A | 72 | 4.88569792161 | -0.6381 | 0.3717 | 13.5459 | -1.0000 | 1.0773 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |
| MCF 10A | Vialinin A | 72 | 12.7930209016 | -0.2051 | 0.1740 | 13.7221 | -0.2088 | 4.9768 |
| BT-20 | HY-17541A | 72 | 9.75522426236 | -0.8815 | 0.3328 | 13.7782 | -0.9458 | 3.0751 |
| HCC1937 | Spautin-1 | 72 | inf | 0.6302 | 0.0761 | 13.9030 | 0.5336 | 0.8715 |
| BT-549 | 1247825-37-1 | 72 | 13.5700541273 | -0.0465 | 0.1614 | 13.9726 | -0.0577 | 3.7355 |
| PDXHCI002 | HBX19818 | 72 | 11.6902936105 | -0.5250 | 0.2522 | 14.0123 | -0.5432 | 4.0591 |
| HCC1937 | Trifluoperazine | 72 | 10.8581477152 | -0.7147 | 0.2805 | 14.1579 | -0.7487 | 3.4491 |
| HCC1419 | Trifluoperazine | 72 | 10.5203345948 | -0.7163 | 0.2648 | 14.1951 | -0.7605 | 3.0865 |
| MDA-MB-231 | Vialinin A | 72 | 11.5071057567 | -0.1762 | 0.1553 | 14.2645 | -0.2485 | 1.8785 |
| HCC202 | Vialinin A | 72 | 7.85110394178 | -0.4245 | 0.2333 | 14.2814 | -0.5846 | 1.2943 |
| MCF7 | Pimozide | 72 | 12.3412443971 | -0.3107 | 0.2210 | 14.3123 | -0.3385 | 3.4890 |
| HCC1500 | P22077 | 72 | 9.09185293504 | -0.4885 | 0.2828 | 14.4725 | -0.6763 | 1.8403 |
| HCC202 | Trifluoperazine | 72 | 10.0332245014 | -0.8634 | 0.3175 | 14.5499 | -0.9578 | 2.8790 |
| BT-549 | SB1-F-22 | 72 | inf | 0.8206 | 0.0279 | 14.6898 | 0.8108 | 2.3064 |
| BT-20 | Trifluoperazine | 72 | 12.3504591925 | -0.7940 | 0.2886 | 14.9777 | -0.8115 | 5.0000 |