Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-20 | Spautin-1 | 72 | inf | 0.5940 | 0.0846 | 8.5501 | 0.5911 | 1.1552 |
| HCC1954 | P22077 | 72 | 3.99414837065 | -0.8173 | 0.3966 | 8.7096 | -0.9912 | 1.4017 |
| PDXHCI002 | 1247825-37-1 | 72 | 7.7918126167 | -0.2501 | 0.2337 | 8.8742 | -0.2609 | 3.2282 |
| SK-BR-3 | 1247825-37-1 | 72 | 8.5852333914 | -0.0647 | 0.2610 | 8.9503 | -0.0631 | 2.8528 |
| MDA-MB-361 | Vialinin A | 72 | 7.75271686789 | -0.4045 | 0.2275 | 8.9559 | -0.3189 | 3.4198 |
| MDA-MB-361 | HBX 41108 | 72 | 2.39879103002 | -0.6248 | 0.4563 | 9.0063 | -1.0000 | 0.8304 |
| HCC1954 | Vialinin A | 72 | 5.65032712603 | -0.4035 | 0.2903 | 9.0380 | -0.4804 | 1.4335 |
| MDA-MB-231 | PB49673382 | 72 | 8.96593855475 | -0.0627 | 0.1864 | 9.0711 | -0.0300 | 5.0000 |
| MCF7 | MI-2 | 72 | 6.8346316028 | -0.3570 | 0.2990 | 9.1547 | -0.4209 | 2.0896 |
| HCC1954 | HY-17541A | 72 | 4.05518549047 | -0.8364 | 0.4858 | 9.2414 | -1.0000 | 1.3338 |
| BT-20 | Vialinin A | 72 | 5.11668603811 | -0.6101 | 0.3004 | 9.2727 | -0.7177 | 1.4971 |
| Hs 578T | PB49673382 | 72 | 9.65679731349 | 0.0485 | 0.1681 | 9.2758 | 0.0479 | 2.5005 |
| PDX1258 | IU1 | 72 | inf | 0.7739 | 0.0478 | 9.3467 | 0.8104 | 5.0000 |
| SK-BR-3 | Spautin-1 | 72 | 52.4840202993 | 0.5136 | 0.1207 | 9.4550 | 0.4402 | 1.2389 |
| HCC1937 | LDN57444 | 72 | 17.7638889324 | 0.2980 | 0.1506 | 9.8052 | 0.2523 | 1.1822 |
| HCC1937 | Vialinin A | 72 | 8.32590505669 | -0.2754 | 0.2500 | 10.0381 | -0.2833 | 2.4000 |
| HCC1419 | SB1-F-22 | 72 | 16.9369859078 | 0.2855 | 0.1259 | 10.0959 | 0.3307 | 2.0935 |
| MDA-MB-231 | HY-17541A | 72 | 4.06512520453 | -0.5762 | 0.3840 | 10.2476 | -0.9077 | 1.1195 |
| HCC1500 | SB1-F-22 | 72 | 8.98637669492 | 0.0425 | 0.2068 | 10.2676 | -0.0717 | 1.0048 |
| MDA-MB-361 | PB49673382 | 72 | 9.80262963264 | -0.2517 | 0.1526 | 10.3320 | -0.1504 | 5.0000 |
| HCC1500 | 1247825-37-1 | 72 | 9.28838157031 | -0.3852 | 0.2439 | 10.3909 | -0.3761 | 5.0000 |
| HCC1500 | Trifluoperazine | 72 | 6.81100307422 | -0.8014 | 0.3931 | 10.4325 | -0.8483 | 2.3266 |
| SK-BR-3 | SB1-F-22 | 72 | 59.7536343747 | 0.4976 | 0.1006 | 10.5121 | 0.4603 | 1.4571 |
| HCC1937 | P22077 | 72 | 9.05043591121 | -0.6741 | 0.2867 | 10.6635 | -0.6354 | 5.0000 |
| MDA-MB-134-VI | SB1-F-22 | 72 | 14.2678654794 | 0.3664 | 0.0349 | 10.7040 | 0.3812 | 5.0000 |