Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | PB49673382 | 72 | 5.75380160264 | 0.0084 | 0.2491 | 5.7215 | 0.0090 | 3.2180 |
| MCF7 | PB49673382 | 72 | 5.67599742388 | -0.0650 | 0.2629 | 5.9577 | -0.0564 | 2.2057 |
| MDA-MB-231 | SB1-F-22 | 72 | inf | 0.7278 | 0.0733 | 6.1857 | 0.7300 | 3.3947 |
| HCC1954 | PB49673382 | 72 | 6.08008183847 | -0.0651 | 0.2802 | 6.1946 | -0.0406 | 4.1865 |
| MDA-MB-134-VI | HBX 41108 | 72 | 2.76621539192 | -0.6472 | 0.4718 | 6.2693 | -0.8129 | 1.1799 |
| MCF7 | Spautin-1 | 72 | 21.2766901138 | 0.4529 | 0.1281 | 6.4229 | 0.4329 | 1.6764 |
| MCF 10A | MI-2 | 72 | 5.79831624395 | -0.2953 | 0.3052 | 6.4633 | -0.2594 | 3.8494 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| PDX1328 | MI-2 | 72 | 5.25760821785 | -0.9161 | 0.4330 | 6.4858 | -0.9284 | 5.0000 |
| MDA-MB-134-VI | Degrasyn | 72 | 5.55416643616 | -0.7023 | 0.4475 | 6.5896 | -0.6754 | 5.0000 |
| CAMA-1 | Spautin-1 | 72 | 8.38966554919 | 0.1933 | 0.2334 | 6.6491 | 0.1026 | 0.9877 |
| HCC1428 | PB49673382 | 72 | 7.01354580048 | -0.0082 | 0.2607 | 6.7113 | 0.0347 | 1.6331 |
| PDXHCI002 | Pimozide | 72 | 3.73166784701 | -0.4762 | 0.4161 | 6.9559 | -0.6294 | 1.3085 |
| MDA-MB-361 | P22077 | 72 | 4.13836928662 | -0.7524 | 0.4217 | 7.0578 | -0.8139 | 1.8098 |
| MDA-MB-134-VI | Spautin-1 | 72 | 6.41375749525 | -0.2188 | 0.3340 | 7.1071 | -0.1453 | 2.4851 |
| MCF7 | Vialinin A | 72 | 6.03216171414 | -0.2574 | 0.2814 | 7.1157 | -0.2692 | 2.6069 |
| PDX1258 | Spautin-1 | 72 | inf | 0.6270 | 0.1154 | 7.2635 | 0.5872 | 0.8220 |
| HCC1419 | HY-17542 | 72 | inf | 0.8046 | 0.0234 | 7.3179 | 0.8511 | 5.0000 |
| T47D | Vialinin A | 72 | 5.62945811704 | -0.3676 | 0.2949 | 7.5227 | -0.3834 | 1.9635 |
| MDA-MB-361 | Spautin-1 | 72 | 6.94135435106 | -0.1974 | 0.2123 | 7.5347 | -0.1634 | 3.4474 |
| HCC1428 | HY-17541A | 72 | 2.47757925824 | -0.8052 | 0.5062 | 7.7740 | -1.0000 | 0.9607 |
| MCF 10A | 1247825-37-1 | 72 | 7.50677192458 | -0.0271 | 0.2339 | 7.8926 | -0.0577 | 2.1809 |
| BT-20 | P22077 | 72 | 5.68690045385 | -0.8029 | 0.3725 | 7.9927 | -0.8136 | 2.8380 |
| Hs 578T | Vialinin A | 72 | 5.33738832012 | -0.3425 | 0.2871 | 8.1284 | -0.4124 | 1.4299 |
| HCC1954 | IU1 | 72 | inf | 0.7969 | 0.0254 | 8.5142 | 0.7979 | 1.8182 |