Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1428 | SJB3-019A | 72 | 0.367074889212 | -0.7873 | 0.9956 | 0.4852 | -0.7833 | 3.3771 |
| Hs 578T | SJB2-043 | 72 | 0.328943396017 | -0.5256 | 0.7088 | 0.4990 | -0.5345 | 1.7452 |
| HCC1954 | Pevonedistat | 72 | 0.316056841639 | -0.3881 | 0.7332 | 0.4991 | -0.3610 | 1.1895 |
| PDX1328 | HY-50737A | 72 | 0.2644727784 | -0.8890 | 1.0078 | 0.4995 | -0.8567 | 1.5697 |
| PDX1258 | HBX 41108 | 72 | 0.19093097022 | -0.5289 | 0.8289 | 0.5067 | -0.5544 | 0.7646 |
| T47D | MI-2 | 72 | 0.443682151865 | -0.4886 | 0.7738 | 0.5068 | -0.4479 | 4.8114 |
| MCF7 | b-AP15 | 72 | 0.3096452845 | -0.3697 | 0.7380 | 0.5354 | -0.3883 | 1.0497 |
| MCF7 | HBX 41108 | 72 | 0.390147535667 | -0.2149 | 0.6730 | 0.5376 | -0.2563 | 1.2906 |
| MDA-MB-134-VI | SJB3-019A | 72 | 0.38974102992 | -0.8219 | 0.9800 | 0.5388 | -0.8154 | 2.9868 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| PDX1258 | SJB3-019A | 72 | 0.465986460631 | -0.5823 | 0.7715 | 0.5616 | -0.5695 | 4.0736 |
| SK-BR-3 | SJB2-043 | 72 | 0.397342856958 | -0.6773 | 0.7194 | 0.5909 | -0.6730 | 2.1483 |
| HCC1954 | HY-50737A | 72 | 0.358997904545 | -0.5501 | 0.8394 | 0.6036 | -0.5719 | 1.4677 |
| T47D | SJB2-043 | 72 | 0.418884416082 | -0.3821 | 0.5842 | 0.6165 | -0.3642 | 1.4158 |
| BT-20 | MI-2 | 72 | 0.409633050522 | -0.7406 | 0.9227 | 0.6203 | -0.7720 | 2.2499 |
| CAMA-1 | MI-2 | 72 | 0.530718147156 | -0.4633 | 0.7592 | 0.6284 | -0.4414 | 3.7466 |
| MCF 10A | HBX 41108 | 72 | 0.57601885416 | -0.0685 | 0.5834 | 0.6298 | -0.1204 | 2.4159 |
| MDA-MB-231 | SB1-F-21 | 72 | 0.508989399047 | -0.2031 | 0.6186 | 0.6310 | -0.2064 | 1.6087 |
| MDA-MB-231 | SJB2-043 | 72 | 0.531717815307 | -0.3147 | 0.5316 | 0.6346 | -0.2713 | 2.4513 |
| HCC1937 | SJB2-043 | 72 | 0.396049351375 | -0.5581 | 0.6542 | 0.6443 | -0.5754 | 1.5740 |
| HCC1419 | Pevonedistat | 72 | 0.633958608318 | -0.0652 | 0.4905 | 0.6588 | -0.0594 | 2.9213 |
| HCC202 | SJB2-043 | 72 | 0.34979801402 | -0.6438 | 0.6718 | 0.6597 | -0.6491 | 1.3117 |
| MDA-MB-134-VI | Sepantronium | 72 | 0.188092865815 | -0.8332 | 0.9138 | 0.6637 | -0.8337 | 0.7781 |
| BT-549 | MI-2 | 72 | 0.571326549598 | -0.4518 | 0.7504 | 0.6753 | -0.4619 | 3.9147 |
| HCC1954 | SJB3-019A | 72 | 0.514424957783 | -0.7154 | 0.8423 | 0.6815 | -0.7101 | 3.1432 |