Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF 10A | Pevonedistat | 72 | 0.283189283641 | -0.1451 | 0.6453 | 0.3283 | -0.1036 | 1.2735 |
| CAMA-1 | SJB3-019A | 72 | 0.282886176656 | -0.5665 | 0.8783 | 0.3283 | -0.4948 | 4.6169 |
| BT-549 | HY-50737A | 72 | 0.248578831213 | -0.3321 | 0.8077 | 0.3314 | -0.3617 | 1.8923 |
| HCC1937 | SJB3-019A | 72 | 0.22094135853 | -0.6386 | 0.9798 | 0.3369 | -0.6446 | 1.9637 |
| MDA-MB-231 | Pevonedistat | 72 | 0.304844361864 | -0.2071 | 0.6496 | 0.3496 | -0.1395 | 1.7956 |
| T47D | SJB3-019A | 72 | 0.197447266274 | -0.5628 | 0.9021 | 0.3562 | -0.5619 | 1.2767 |
| HCC1419 | SJB3-019A | 72 | 0.264021428661 | -0.7295 | 0.9719 | 0.3757 | -0.7072 | 2.4982 |
| PDX1328 | SJB2-043 | 72 | 0.283039978056 | -0.9550 | 0.9369 | 0.3776 | -0.9607 | 3.7191 |
| BT-549 | SJB3-019A | 72 | 0.339491273677 | -0.3726 | 0.8009 | 0.3799 | -0.3779 | 5.0000 |
| BT-20 | SJB3-019A | 72 | 0.340138717913 | -0.6009 | 0.8217 | 0.3987 | -0.6067 | 5.0000 |
| MCF7 | Mitoxantrone | 72 | 0.0169144908308 | -0.7736 | 1.0817 | 0.3991 | -1.0000 | 0.3475 |
| HCC202 | SJB3-019A | 72 | 0.309480434729 | -0.7379 | 0.9677 | 0.4087 | -0.7302 | 3.2363 |
| MDA-MB-134-VI | SB1-F-21 | 72 | 0.200334316749 | -0.6803 | 0.9163 | 0.4114 | -0.6457 | 1.1523 |
| HCC1500 | SB1-F-21 | 72 | 0.30399978751 | -0.4684 | 0.8004 | 0.4116 | -0.4456 | 2.1021 |
| MCF7 | SJB2-043 | 72 | 0.361790238142 | -0.2773 | 0.6009 | 0.4120 | -0.2857 | 3.4782 |
| PDXHCI002 | SJB3-019A | 72 | 0.305258876445 | -0.5784 | 0.8656 | 0.4150 | -0.5629 | 2.4552 |
| HCC1419 | b-AP15 | 72 | 0.193977861969 | -0.7204 | 0.9296 | 0.4205 | -0.7037 | 1.1355 |
| MDA-MB-231 | SJB3-019A | 72 | 0.347120433929 | -0.3529 | 0.7664 | 0.4218 | -0.3365 | 2.6418 |
| HCC1419 | HY-50737A | 72 | 0.231678580625 | -0.6762 | 0.9645 | 0.4319 | -0.6991 | 1.4044 |
| HCC202 | HY-50737A | 72 | 0.256783423743 | -0.6392 | 0.8916 | 0.4419 | -0.6154 | 1.4780 |
| PDX1258 | Pevonedistat | 72 | 0.270220542659 | -0.3092 | 0.7119 | 0.4435 | -0.2984 | 0.9444 |
| MCF 10A | SJB3-019A | 72 | 0.405445696252 | -0.1954 | 0.6695 | 0.4504 | -0.1982 | 3.1747 |
| SK-BR-3 | SB1-F-21 | 72 | 0.26463962594 | -0.4562 | 0.7702 | 0.4655 | -0.4299 | 1.0988 |
| CAMA-1 | SJB2-043 | 72 | 0.372483737956 | -0.4977 | 0.7091 | 0.4732 | -0.5024 | 2.9069 |
| BT-20 | LDN57444 | 72 | 0.273589049961 | -0.5384 | 0.7238 | 0.4768 | -0.3750 | 1.0074 |