Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Pimozide | 72 | 4.05486946769 | -0.5520 | 0.4336 | 12.8412 | -1.0000 | 0.9530 |
| MDA-MB-134-VI | Pimozide | 72 | 11.8000728863 | -0.6444 | 0.3046 | 16.3244 | -0.7190 | 2.7460 |
| SK-BR-3 | Pevonedistat | 72 | 0.0849225267347 | 0.0282 | 0.7128 | 0.0790 | 0.0487 | 1.4169 |
| HCC1937 | Pevonedistat | 72 | 0.0855702491458 | -0.1081 | 0.7701 | 0.0915 | -0.0540 | 1.5279 |
| MCF7 | Pevonedistat | 72 | 0.150383057079 | -0.0374 | 0.6766 | 0.1518 | -0.0061 | 1.3103 |
| BT-20 | Pevonedistat | 72 | 0.777542936783 | -0.2693 | 0.5455 | 0.9974 | -0.2189 | 1.4577 |
| PDXHCI002 | Pevonedistat | 72 | 0.0433461990142 | -0.5207 | 1.1704 | 0.0659 | -0.5145 | 1.6896 |
| HCC1419 | Pevonedistat | 72 | 0.633958608318 | -0.0652 | 0.4905 | 0.6588 | -0.0594 | 2.9213 |
| HCC202 | Pevonedistat | 72 | 0.22686190551 | -0.1206 | 0.6609 | 0.2532 | -0.0750 | 1.2710 |
| PDX1328 | Pevonedistat | 72 | inf | -0.7089 | -0.4505 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-231 | Pevonedistat | 72 | 0.304844361864 | -0.2071 | 0.6496 | 0.3496 | -0.1395 | 1.7956 |
| HCC1806 | Pevonedistat | 72 | 0.0335529495438 | -0.2883 | 1.0267 | 0.0419 | -0.2494 | 1.8239 |
| MCF 10A | Pevonedistat | 72 | 0.283189283641 | -0.1451 | 0.6453 | 0.3283 | -0.1036 | 1.2735 |
| Hs 578T | Pevonedistat | 72 | 0.250318851881 | -0.1834 | 0.6322 | 0.2775 | -0.0801 | 1.4401 |
| MDA-MB-361 | Pevonedistat | 72 | 0.105133263812 | -0.3279 | 0.8618 | 0.1270 | -0.2800 | 2.3487 |
| BT-549 | Pevonedistat | 72 | 0.209348073627 | -0.2452 | 0.7301 | 0.2903 | -0.2281 | 1.1500 |
| HCC1500 | Pevonedistat | 72 | 0.137214417377 | 0.1450 | 0.5633 | 0.0907 | 0.2227 | 1.4231 |
| CAMA-1 | Pevonedistat | 72 | 0.0450559209474 | -0.1660 | 0.9043 | 0.0502 | -0.1172 | 1.9572 |
| MDA-MB-134-VI | Pevonedistat | 72 | 0.0632002423546 | -0.2210 | 0.8831 | 0.0747 | -0.1673 | 1.7325 |
| T47D | Pevonedistat | 72 | 0.0485963385259 | -0.0543 | 0.9154 | 0.0536 | -0.1256 | 2.2893 |
| HCC1428 | Pevonedistat | 72 | 0.0551476845561 | -0.1563 | 0.9412 | 0.0662 | -0.1995 | 1.8358 |
| HCC1954 | Pevonedistat | 72 | 0.316056841639 | -0.3881 | 0.7332 | 0.4991 | -0.3610 | 1.1895 |
| PDX1258 | Pevonedistat | 72 | 0.270220542659 | -0.3092 | 0.7119 | 0.4435 | -0.2984 | 0.9444 |
| BT-20 | PB49673382 | 72 | 3.13374675059 | 0.0918 | 0.3024 | 2.9808 | 0.1107 | 5.0000 |
| HCC1937 | PB49673382 | 72 | 7.51602525958 | 0.2509 | 0.2135 | 5.4225 | 0.2446 | 2.0574 |