Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC202 | HY-50736 | 72 | 0.0428061682624 | -0.4761 | 1.2531 | 0.0686 | -0.5861 | 1.6431 |
| SK-BR-3 | Mitoxantrone | 72 | 0.00831816680715 | -0.7263 | 1.2354 | 0.0647 | -0.7477 | 0.4458 |
| T47D | Sepantronium | 72 | 0.0256731457276 | -0.5680 | 1.2354 | 0.0464 | -0.5390 | 1.2377 |
| MDA-MB-231 | Mitoxantrone | 72 | 0.000221543574526 | -0.5445 | 1.2292 | 0.0275 | -0.8714 | 0.2093 |
| HCC1937 | Sepantronium | 72 | 0.0274217558915 | -0.5570 | 1.2238 | 0.0525 | -0.5494 | 1.1409 |
| PDX1258 | HY-50737A | 72 | 0.0413916873909 | -0.6402 | 1.2194 | 0.0709 | -0.5806 | 1.4319 |
| HCC202 | Mitoxantrone | 72 | 0.00434457297625 | -0.7112 | 1.2184 | 0.1443 | -1.0000 | 0.3136 |
| MCF7 | Sepantronium | 72 | 0.00846233647125 | -0.3440 | 1.2181 | 0.0126 | -0.3282 | 1.2567 |
| HCC1954 | b-AP15 | 72 | 0.0709214214205 | -0.7172 | 1.2064 | 0.1119 | -0.6936 | 1.9069 |
| CAMA-1 | HY-50737A | 72 | 0.0398550490328 | -0.3484 | 1.1830 | 0.0537 | -0.4527 | 2.1642 |
| HCC1954 | Mitoxantrone | 72 | 0.0141773373515 | -0.6799 | 1.1790 | 0.1017 | -0.7312 | 0.4574 |
| PDXHCI002 | Pevonedistat | 72 | 0.0433461990142 | -0.5207 | 1.1704 | 0.0659 | -0.5145 | 1.6896 |
| PDX1258 | Mitoxantrone | 72 | 0.007407644519 | -0.6933 | 1.1643 | 0.2222 | -1.0000 | 0.3230 |
| T47D | Mitoxantrone | 72 | 5.66232793817e-05 | -0.4434 | 1.1468 | 0.0899 | -1.0000 | 0.1491 |
| BT-549 | Sepantronium | 72 | 0.0268606049638 | -0.4073 | 1.1453 | 0.0366 | -0.3708 | 1.7888 |
| PDX1328 | b-AP15 | 72 | 0.183369061603 | -0.9168 | 1.1450 | 0.2761 | -0.8858 | 2.4900 |
| PDXHCI002 | b-AP15 | 72 | 0.0451916121201 | -0.5737 | 1.1338 | 0.0762 | -0.5135 | 1.3527 |
| HCC1419 | Sepantronium | 72 | 0.0796965605305 | -0.7110 | 1.1081 | 0.1781 | -0.6956 | 1.0840 |
| HCC1428 | b-AP15 | 72 | 0.0647974209893 | -0.7164 | 1.1058 | 0.1041 | -0.5730 | 1.6094 |
| HCC1954 | HY-50736 | 72 | 0.0820968061449 | -0.4069 | 1.1010 | 0.1207 | -0.5219 | 1.8530 |
| SK-BR-3 | b-AP15 | 72 | 0.0708405930018 | -0.6425 | 1.0904 | 0.1445 | -0.6152 | 1.1256 |
| MCF 10A | Sepantronium | 72 | 0.00774537160659 | -0.1459 | 1.0865 | 0.0087 | -0.1294 | 1.9809 |
| HCC202 | b-AP15 | 72 | 0.101469191263 | -0.7256 | 1.0819 | 0.1809 | -0.6658 | 1.4645 |
| MCF7 | Mitoxantrone | 72 | 0.0169144908308 | -0.7736 | 1.0817 | 0.3991 | -1.0000 | 0.3475 |
| HCC1500 | HY-50737A | 72 | 0.114212661737 | -0.5828 | 1.0742 | 0.1811 | -0.6211 | 1.7514 |