Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1500 | PB49673382 | 72 | 2.15663277537 | -0.3642 | 0.4919 | 3.0687 | -0.4022 | 1.6734 |
| MCF 10A | Degrasyn | 72 | 1.40857817808 | -0.1567 | 0.4917 | 1.5039 | -0.1937 | 5.0000 |
| HCC1419 | Pevonedistat | 72 | 0.633958608318 | -0.0652 | 0.4905 | 0.6588 | -0.0594 | 2.9213 |
| MDA-MB-361 | HY-50737A | 72 | 2.34765001883 | -0.5291 | 0.4893 | 3.2880 | -0.5082 | 2.0817 |
| MDA-MB-134-VI | SJB2-043 | 72 | 1.00401948456 | -0.3627 | 0.4871 | 1.7779 | -0.4717 | 1.1627 |
| HCC1954 | HY-17541A | 72 | 4.05518549047 | -0.8364 | 0.4858 | 9.2414 | -1.0000 | 1.3338 |
| MDA-MB-361 | MI-2 | 72 | 3.80487472111 | -0.7848 | 0.4779 | 4.6826 | -0.7574 | 4.4428 |
| Hs 578T | HY-17541A | 72 | 2.67034332565 | -0.5936 | 0.4776 | 3.6894 | -0.5809 | 2.3850 |
| BT-549 | Degrasyn | 72 | 2.03345345035 | -0.2544 | 0.4762 | 2.2668 | -0.2681 | 3.9517 |
| HCC1806 | HBX 41108 | 72 | 1.89335739104 | -0.2790 | 0.4749 | 2.4303 | -0.2907 | 1.8354 |
| MDA-MB-134-VI | HBX 41108 | 72 | 2.76621539192 | -0.6472 | 0.4718 | 6.2693 | -0.8129 | 1.1799 |
| PDX1258 | SJB2-043 | 72 | 0.885786050221 | -0.4791 | 0.4693 | 1.0043 | -0.4368 | 5.0000 |
| HCC1806 | Degrasyn | 72 | 2.75238625089 | -0.3101 | 0.4592 | 3.0534 | -0.3402 | 5.0000 |
| MDA-MB-361 | HBX 41108 | 72 | 2.39879103002 | -0.6248 | 0.4563 | 9.0063 | -1.0000 | 0.8304 |
| HCC1806 | MI-2 | 72 | 3.9059429509 | -0.5803 | 0.4525 | 4.7751 | -0.5651 | 3.7640 |
| PDX1258 | P22077 | 72 | 3.1997536366 | -0.5772 | 0.4517 | 4.5424 | -0.5888 | 2.2210 |
| MDA-MB-134-VI | Degrasyn | 72 | 5.55416643616 | -0.7023 | 0.4475 | 6.5896 | -0.6754 | 5.0000 |
| SK-BR-3 | Pimozide | 72 | 4.05486946769 | -0.5520 | 0.4336 | 12.8412 | -1.0000 | 0.9530 |
| PDX1328 | MI-2 | 72 | 5.25760821785 | -0.9161 | 0.4330 | 6.4858 | -0.9284 | 5.0000 |
| HCC1937 | Degrasyn | 72 | 3.23543546484 | -0.4694 | 0.4319 | 3.6822 | -0.4546 | 5.0000 |
| MCF7 | Degrasyn | 72 | 2.92659494703 | -0.3734 | 0.4302 | 3.6506 | -0.3648 | 2.4786 |
| CAMA-1 | LDN57444 | 72 | 2.83119526 | -0.3122 | 0.4296 | 3.1629 | -0.2963 | 4.2007 |
| MDA-MB-361 | P22077 | 72 | 4.13836928662 | -0.7524 | 0.4217 | 7.0578 | -0.8139 | 1.8098 |
| T47D | P22077 | 72 | 3.7378149825 | -0.5532 | 0.4192 | 4.7330 | -0.5353 | 3.0835 |
| MCF 10A | SJB2-043 | 72 | 0.862612545381 | -0.1149 | 0.4174 | 0.9321 | -0.1040 | 2.4388 |