Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | Mitoxantrone | 72 | 0.0230093894489 | -0.2390 | 0.9504 | 0.0794 | -0.3700 | 0.4470 |
| SK-BR-3 | Pevonedistat | 72 | 0.0849225267347 | 0.0282 | 0.7128 | 0.0790 | 0.0487 | 1.4169 |
| PDXHCI002 | b-AP15 | 72 | 0.0451916121201 | -0.5737 | 1.1338 | 0.0762 | -0.5135 | 1.3527 |
| MDA-MB-134-VI | Pevonedistat | 72 | 0.0632002423546 | -0.2210 | 0.8831 | 0.0747 | -0.1673 | 1.7325 |
| HCC202 | Sepantronium | 72 | 0.0290947525156 | -0.7576 | 1.3115 | 0.0737 | -0.7522 | 0.9876 |
| PDX1258 | HY-50737A | 72 | 0.0413916873909 | -0.6402 | 1.2194 | 0.0709 | -0.5806 | 1.4319 |
| HCC202 | HY-50736 | 72 | 0.0428061682624 | -0.4761 | 1.2531 | 0.0686 | -0.5861 | 1.6431 |
| HCC1428 | Pevonedistat | 72 | 0.0551476845561 | -0.1563 | 0.9412 | 0.0662 | -0.1995 | 1.8358 |
| PDXHCI002 | Pevonedistat | 72 | 0.0433461990142 | -0.5207 | 1.1704 | 0.0659 | -0.5145 | 1.6896 |
| BT-549 | HY-50736 | 72 | 0.0483582820394 | -0.3009 | 1.0550 | 0.0658 | -0.3461 | 1.7080 |
| SK-BR-3 | Mitoxantrone | 72 | 0.00831816680715 | -0.7263 | 1.2354 | 0.0647 | -0.7477 | 0.4458 |
| MCF7 | HY-50736 | 72 | 0.048225043242 | -0.1348 | 0.9464 | 0.0630 | -0.2053 | 1.2899 |
| HCC1428 | HY-50737A | 72 | 0.0382137561414 | -0.7451 | 1.3903 | 0.0607 | -0.7570 | 1.9896 |
| HCC1806 | Mitoxantrone | 72 | 0.0444174670492 | -0.2704 | 0.9420 | 0.0607 | -0.2125 | 1.1318 |
| CAMA-1 | HY-50737A | 72 | 0.0398550490328 | -0.3484 | 1.1830 | 0.0537 | -0.4527 | 2.1642 |
| T47D | Pevonedistat | 72 | 0.0485963385259 | -0.0543 | 0.9154 | 0.0536 | -0.1256 | 2.2893 |
| HCC1937 | Sepantronium | 72 | 0.0274217558915 | -0.5570 | 1.2238 | 0.0525 | -0.5494 | 1.1409 |
| CAMA-1 | Pevonedistat | 72 | 0.0450559209474 | -0.1660 | 0.9043 | 0.0502 | -0.1172 | 1.9572 |
| T47D | Sepantronium | 72 | 0.0256731457276 | -0.5680 | 1.2354 | 0.0464 | -0.5390 | 1.2377 |
| HCC1806 | Pevonedistat | 72 | 0.0335529495438 | -0.2883 | 1.0267 | 0.0419 | -0.2494 | 1.8239 |
| SK-BR-3 | Sepantronium | 72 | 0.0223899931737 | -0.6896 | 1.3675 | 0.0376 | -0.6471 | 1.6002 |
| BT-549 | Sepantronium | 72 | 0.0268606049638 | -0.4073 | 1.1453 | 0.0366 | -0.3708 | 1.7888 |
| MDA-MB-361 | Mitoxantrone | 72 | 0.00180293182659 | -0.9488 | 1.4412 | 0.0357 | -1.0000 | 0.3678 |
| PDX1328 | Sepantronium | 72 | 0.0218983386219 | -0.9670 | 1.5930 | 0.0347 | -0.5708 | 1.6579 |
| HCC1937 | HY-50736 | 72 | 0.0175748900813 | -0.4737 | 1.2706 | 0.0315 | -0.5040 | 1.1960 |