Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF7 | SB1-F-21 | 72 | 0.615140979311 | -0.3940 | 0.6577 | 0.7749 | -0.3444 | 2.2705 |
| MCF7 | SB1-F-22 | 72 | 13.3623714813 | 0.2021 | 0.1288 | 11.5010 | 0.2638 | 5.0000 |
| MCF7 | SJB2-043 | 72 | 0.361790238142 | -0.2773 | 0.6009 | 0.4120 | -0.2857 | 3.4782 |
| MCF7 | SJB3-019A | 72 | 0.181501994106 | -0.2939 | 0.8146 | 0.2092 | -0.2679 | 3.0164 |
| MCF7 | STK547622 | 72 | inf | 1.0181 | -0.0093 | 0.0000 | 1.0000 | 0.0100 |
| MCF7 | Vialinin A | 72 | 6.03216171414 | -0.2574 | 0.2814 | 7.1157 | -0.2692 | 2.6069 |
| MCF7 | Degrasyn | 72 | 2.92659494703 | -0.3734 | 0.4302 | 3.6506 | -0.3648 | 2.4786 |
| MCF7 | Sepantronium | 72 | 0.00846233647125 | -0.3440 | 1.2181 | 0.0126 | -0.3282 | 1.2567 |
| MCF7 | b-AP15 | 72 | 0.3096452845 | -0.3697 | 0.7380 | 0.5354 | -0.3883 | 1.0497 |
| MCF7 | Doxycycline | 72 | inf | 0.9910 | 0.0087 | 0.0000 | 0.9840 | 0.0100 |
| MCF7 | Mitoxantrone | 72 | 0.0169144908308 | -0.7736 | 1.0817 | 0.3991 | -1.0000 | 0.3475 |
| MCF7 | P22077 | 72 | 10.7385958579 | -0.3409 | 0.2082 | 11.8606 | -0.3218 | 5.0000 |
| MCF7 | Pimozide | 72 | 12.3412443971 | -0.3107 | 0.2210 | 14.3123 | -0.3385 | 3.4890 |
| MCF7 | Spautin-1 | 72 | 21.2766901138 | 0.4529 | 0.1281 | 6.4229 | 0.4329 | 1.6764 |
| MCF7 | Trifluoperazine | 72 | 11.3097883651 | -0.4096 | 0.2127 | 13.2613 | -0.4283 | 3.8867 |
| MCF7 | z-VAE(OMe)-fmk | 72 | inf | 1.0118 | -0.0177 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-134-VI | 1247825-37-1 | 72 | 10.4154396199 | -0.1095 | 0.2026 | 10.7700 | -0.0911 | 5.0000 |
| MDA-MB-134-VI | USP7-IN-1 | 72 | inf | 0.7107 | 0.0309 | 0.0000 | 0.9508 | 0.0100 |
| MDA-MB-134-VI | GW7647 | 72 | inf | 1.0004 | -0.0983 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-134-VI | HBX19818 | 72 | 16.8677883349 | -0.7570 | 0.1742 | 25.9920 | -1.0000 | 2.5408 |
| MDA-MB-134-VI | HBX 41108 | 72 | 2.76621539192 | -0.6472 | 0.4718 | 6.2693 | -0.8129 | 1.1799 |
| MDA-MB-134-VI | HY-17541A | 72 | 7.95461844294 | -0.9278 | 0.2754 | 16.0755 | -1.0000 | 1.5615 |
| MDA-MB-134-VI | HY-17542 | 72 | inf | 0.5701 | 0.0598 | 0.0000 | 0.9013 | 0.0100 |
| MDA-MB-134-VI | HY-50736 | 72 | 1.15751643186 | -0.5688 | 0.6417 | 1.9555 | -0.5934 | 1.4920 |
| MDA-MB-134-VI | HY-50737A | 72 | 5.9031368352 | -0.5171 | 0.3304 | 19.3421 | -0.9632 | 0.9048 |