Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | Cabozantinib | VEGFR2/MET | RTK | 5.7589 | 0.2895 | 0.0383 | 0.0198 | 4.7896 | 4.9143 | 0.99303 |
| MDA-MB-453 | Cabozantinib | VEGFR2/MET | RTK | 9.0899 | 0.4645 | -0.0045 | 0.0208 | 4.5355 | 6.5788 | 0.94161 |
| MDA-MB-361 | Cabozantinib | VEGFR2/MET | RTK | Inf | 0.6624 | 0.0628 | -0.0003 | 4.9832 | 4.0443 | 0.74358 |
| PDX1328 | Cabozantinib | VEGFR2/MET | RTK | 1.8826 | -0.1622 | 0.2366 | 0.0206 | 0.7816 | 7.6768 | 0.95877 |
| SUM1315MO2 | Cabozantinib | VEGFR2/MET | RTK | 4.5316 | 0.1095 | 0.1089 | 0.0163 | 1.1058 | 12.2361 | 0.99069 |
| HCC1143 | Cediranib | VEGFR/cKIT | RTK | 3.7314 | 0.0093 | 0.1653 | 0.0292 | 1.0590 | 10.5294 | 0.98332 |
| BT-20 | Cediranib | VEGFR/cKIT | RTK | 5.6982 | 0.2210 | 0.0383 | 0.0150 | 2.7852 | 5.3221 | 0.97585 |
| HCC1419 | Cediranib | VEGFR/cKIT | RTK | 5.0599 | -0.0329 | 0.0545 | 0.0124 | 4.9952 | 5.1984 | 0.99032 |
| PDX1258 | Cediranib | VEGFR/cKIT | RTK | 4.7159 | -0.5611 | 0.0744 | 0.0681 | 4.9799 | 5.5703 | 0.99375 |
| MDA-MB-134-VI | Cediranib | VEGFR/cKIT | RTK | 4.2103 | -0.9999 | 0.0977 | 0.0979 | 5.0000 | 5.2449 | 0.99321 |
| HCC1937 | Cediranib | VEGFR/cKIT | RTK | 7.9267 | 0.2784 | 0.0440 | 0.0316 | 3.5480 | 8.352 | 0.99376 |
| HCC38 | Cediranib | VEGFR/cKIT | RTK | 1.5907 | -0.2044 | 0.2096 | 0.0416 | 1.0695 | 3.1564 | 0.98723 |
| CAL-85-1 | Cediranib | VEGFR/cKIT | RTK | 2.4003 | -0.2379 | 0.1869 | 0.0514 | 1.1002 | 6.5151 | 0.99569 |
| HCC70 | Cediranib | VEGFR/cKIT | RTK | 4.5386 | -0.3262 | 0.0890 | 0.0440 | 2.2440 | 7.4053 | 0.99062 |
| SK-BR-3 | Cediranib | VEGFR/cKIT | RTK | 6.1955 | -0.5397 | 0.0755 | 0.0528 | 4.8242 | 7.7773 | 0.99548 |
| MCF 10A | Cediranib | VEGFR/cKIT | RTK | 9.6397 | 0.4781 | 0.0310 | 0.0012 | 3.3546 | 8.1 | 0.99825 |
| PDX1328 | Cediranib | VEGFR/cKIT | RTK | 0.95412 | -0.8534 | 0.3764 | 0.0972 | 1.1127 | 2.5609 | 0.95134 |
| MDA-MB-361 | Cediranib | VEGFR/cKIT | RTK | 2.2171 | -0.9803 | 0.2895 | 0.1040 | 2.2939 | 3.5791 | 0.96048 |
| HCC1395 | Cediranib | VEGFR/cKIT | RTK | 1.571 | -0.4825 | 0.2460 | 0.0671 | 1.0270 | 4.579 | 0.97022 |
| HCC1500 | Cediranib | VEGFR/cKIT | RTK | 3.8594 | -0.8084 | 0.1304 | 0.0735 | 3.4916 | 5.2864 | 0.99235 |
| HCC1954 | Cediranib | VEGFR/cKIT | RTK | 4.092 | -0.3202 | 0.0756 | 0.0534 | 4.9589 | 4.5507 | 0.99308 |
| MDA-MB-231 | Cediranib | VEGFR/cKIT | RTK | 5.0964 | -0.3620 | 0.1160 | 0.0659 | 2.7537 | 7.595 | 0.99835 |
| MDA-MB-468 | Cediranib | VEGFR/cKIT | RTK | 3.9154 | -0.7083 | 0.1649 | 0.0970 | 3.0423 | 5.6183 | 0.9962 |
| CAL-51 | Cediranib | VEGFR/cKIT | RTK | 3.0488 | -0.1033 | 0.1710 | 0.0517 | 1.0331 | 8.8303 | 0.9776 |
| HME1 | Cediranib | VEGFR/cKIT | RTK | 7.6446 | 0.0275 | 0.0214 | 0.0244 | 4.8856 | 8.7954 | 0.98095 |