Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | Ceritinib | ALK | RTK | 0.26636 | -0.9910 | 0.5462 | 0.1443 | 0.8263 | 1.0067 | 0.97236 |
| PDX1258 | Ceritinib | ALK | RTK | 2.081 | -0.6841 | 0.2165 | 0.0876 | 1.5671 | 4.1949 | 0.9759 |
| HCC70 | Ceritinib | ALK | RTK | 3.1923 | -0.8808 | 0.1379 | 0.0703 | 5.0000 | 3.9213 | 0.99483 |
| HCC1500 | Ceritinib | ALK | RTK | 1.4068 | -0.9535 | 0.2988 | 0.1206 | 1.5745 | 2.8266 | 0.97255 |
| T47D | Ceritinib | ALK | RTK | 1.5629 | -0.8550 | 0.3123 | 0.1208 | 1.6029 | 3.1015 | 0.97809 |
| HCC1143 | Ceritinib | ALK | RTK | 1.4479 | -0.4219 | 0.2848 | 0.0621 | 1.0347 | 4.1868 | 0.99172 |
| CAL-85-1 | Ceritinib | ALK | RTK | 0.74024 | -0.5961 | 0.3725 | 0.0586 | 0.9797 | 2.2143 | 0.9988 |
| HCC1954 | Ceritinib | ALK | RTK | 2.3105 | -0.4446 | 0.1668 | 0.0701 | 2.4217 | 3.1138 | 0.99363 |
| PDXHCI002 | Ceritinib | ALK | RTK | 0.33749 | -0.6341 | 0.5101 | 0.1873 | 1.5133 | 0.59866 | 0.99609 |
| MDA-MB-134-VI | Ceritinib | ALK | RTK | 0.13159 | -0.9992 | 0.6654 | 0.1723 | 0.9173 | 0.43587 | 0.98922 |
| CAL-120 | Ceritinib | ALK | RTK | 0.79939 | -0.4322 | 0.3366 | 0.1170 | 1.0290 | 1.7983 | 0.99115 |
| HCC1937 | Ceritinib | ALK | RTK | 3.5257 | -0.5730 | 0.1368 | 0.0730 | 2.2956 | 5.6897 | 0.99584 |
| MDA-MB-157 | Ceritinib | ALK | RTK | 0.48405 | -0.9264 | 0.4600 | 0.1138 | 0.9467 | 1.5449 | 0.97503 |
| SK-BR-3 | Ceritinib | ALK | RTK | 0.98319 | -0.8254 | 0.3174 | 0.0975 | 1.2454 | 2.3754 | 0.98337 |
| CAL-51 | Ceritinib | ALK | RTK | 0.47536 | -0.4763 | 0.4172 | 0.1229 | 1.1654 | 0.88025 | 0.99344 |
| MDA-MB-231 | Ceritinib | ALK | RTK | 0.86565 | -0.3326 | 0.3444 | 0.1014 | 1.9065 | 1.1609 | 0.99581 |
| Hs 578T | Ceritinib | ALK | RTK | 0.96543 | -0.4356 | 0.3052 | 0.1254 | 0.8330 | 3.6097 | 0.98175 |
| BT-20 | Ceritinib | ALK | RTK | 1.5315 | -0.7365 | 0.2591 | 0.1255 | 1.7439 | 2.7905 | 0.99717 |
| BT-549 | Ceritinib | ALK | RTK | 2.961 | -0.2284 | 0.1416 | 0.0526 | 1.8781 | 4.216 | 0.99556 |
| HCC1395 | Ceritinib | ALK | RTK | 1.6025 | -0.6268 | 0.2363 | 0.0809 | 1.8434 | 2.6534 | 0.99554 |
| PDX1328 | ABT-737 | Bcl2/XL | Misc | 1.0279 | -0.8967 | 0.3548 | 0.1542 | 1.3255 | 2.3546 | 0.97784 |
| HCC1954 | ABT-737 | Bcl2/XL | Misc | 9.9512 | 0.4962 | 0.0404 | 0.0618 | 1.0240 | 27.9634 | 0.94601 |
| MDA-MB-231 | ABT-737 | Bcl2/XL | Misc | 3.031 | -0.1204 | 0.1616 | 0.0795 | 1.1097 | 8.1572 | 0.99586 |
| MCF7 | ABT-737 | Bcl2/XL | Misc | 22.5968 | 0.7267 | 0.0146 | 0.0115 | 1.1080 | 29.1513 | 0.88699 |
| MDA-MB-468 | ABT-737 | Bcl2/XL | Misc | 6.0269 | 0.1420 | 0.0860 | 0.0547 | 1.5887 | 12.0342 | 0.98897 |