Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MCF 10A Olaparib
PARP
Misc
59.3998
 0.7945 0.0408 -0.0007 0.6167
350.419
0.98306
HCC1806 Abemaciclib
CDK4/6
Cell cycle
0.59453
 -0.4440 0.3921 0.1035 0.6190
3.5069
0.96621
SK-BR-3 Dasatinib
BCR/ABL
MAPK/nRTK
3.6452
 0.0810 0.0617 0.0233 5.0000
3.5272
0.98252
T47D Olaparib
PARP
Misc
Inf
 0.5304 0.0302 0.0015 4.9632
3.5388
0.95841
SK-BR-3 Olaparib
PARP
Misc
12.0744
 0.5653 0.0429 0.0174 1.0158
35.3887
0.93619
HCC1395 Alpelisib
PI3Ka
PI3K/mTOR
14.2707
 0.6375 0.0319 0.0088 1.2066
35.4714
0.90001
MDA-MB-361 Cediranib
VEGFR/cKIT
RTK
2.2171
 -0.9803 0.2895 0.1040 2.2939
3.5791
0.96048
CAMA-1 Ceritinib
ALK
RTK
1.797
 -0.6988 0.2366 0.0972 1.5849
3.5941
0.99647
Hs 578T Ceritinib
ALK
RTK
0.96543
 -0.4356 0.3052 0.1254 0.8330
3.6097
0.98175
MDA-MB-134-VI Cisplatin
Chemo
Chemotherapy
10.3229
 0.5019 0.0719 -0.0064 0.7594
36.1235
0.92643
MDA-MB-361 Cisplatin
Chemo
Chemotherapy
2.6294
 -0.3498 0.1809 0.0253 2.1659
3.6196
0.98908
SUM1315MO2 Cisplatin
Chemo
Chemotherapy
1.275
 0.2028 0.2961 0.0592 0.4798
3.6243
0.95111
HME1 Cabozantinib
VEGFR2/MET
RTK
3.2402
 -0.1052 0.1020 0.0260 2.6885
3.6278
0.98973
CAMA-1 ABT-737
Bcl2/XL
Misc
Inf
 0.8643 0.0008 0.0221 5.0000
3.6752
0.74188
BT-549 Saracatinib
SRC
MAPK/nRTK
Inf
 0.5558 0.0348 0.0015 3.3790
3.6758
0.97565
HME1 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.6353 0.0365 0.0079 1.2722
3.6876
0.93611
MDA-MB-157 Pictilisib
pan PI3K
PI3K/mTOR
2.0533
 0.1874 0.2583 0.0226 0.3801
36.9459
0.95358
HCC1937 Taselisib
PI3Ka, g, d
PI3K/mTOR
1.2267
 0.1206 0.2771 0.0422 0.5159
3.7186
0.99159
MDA-MB-453 Cediranib
VEGFR/cKIT
RTK
2.7824
 -0.6894 0.1569 0.0768 3.0858
3.7659
0.99464
MDA-MB-134-VI Ipatasertib
AKT
PI3K/mTOR
8.0392
 0.4925 0.0150 0.0096 4.9968
3.7717
0.94642
MCF7 Neratinib
EGFR/HER2
RTK
1.2629
 0.0582 0.1421 0.0220 1.0034
3.7746
0.97694
BT-549 Olaparib
PARP
Misc
11.948
 0.5432 0.0657 0.0130 0.9548
37.7564
0.91931
T47D A-1210477
Mcl-1
Misc
Inf
 0.5752 0.0227 0.0055 5.0000
3.7781
0.96287
HCC1143 Olaparib
PARP
Misc
8.8262
 0.4562 0.0925 0.0158 0.7545
37.8573
0.98047
BT-20 PF-4708671
p70S6K
PI3K/mTOR
15.1446
 0.6601 0.0129 0.0102 1.1942
37.9666
0.89476