Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Cediranib | VEGFR/cKIT | RTK | 0.55083 | -0.5723 | 0.3937 | 0.1358 | 0.6641 | 2.8803 | 0.96002 |
| PDX1328 | Cediranib | VEGFR/cKIT | RTK | 0.95412 | -0.8534 | 0.3764 | 0.0972 | 1.1127 | 2.5609 | 0.95134 |
| MDA-MB-436 | Cediranib | VEGFR/cKIT | RTK | 3.6098 | -0.3824 | 0.1610 | 0.0446 | 1.8229 | 6.595 | 0.98039 |
| HCC1954 | Cediranib | VEGFR/cKIT | RTK | 4.092 | -0.3202 | 0.0756 | 0.0534 | 4.9589 | 4.5507 | 0.99308 |
| SK-BR-3 | Cediranib | VEGFR/cKIT | RTK | 6.1955 | -0.5397 | 0.0755 | 0.0528 | 4.8242 | 7.7773 | 0.99548 |
| HCC38 | Cediranib | VEGFR/cKIT | RTK | 1.5907 | -0.2044 | 0.2096 | 0.0416 | 1.0695 | 3.1564 | 0.98723 |
| HCC1806 | Cediranib | VEGFR/cKIT | RTK | 4.9315 | 0.0954 | 0.0645 | 0.0363 | 4.9998 | 4.7786 | 0.98723 |
| MDA-MB-231 | Cediranib | VEGFR/cKIT | RTK | 5.0964 | -0.3620 | 0.1160 | 0.0659 | 2.7537 | 7.595 | 0.99835 |
| CAL-120 | Cediranib | VEGFR/cKIT | RTK | 1.037 | -0.1243 | 0.2989 | 0.0564 | 0.5757 | 6.9922 | 0.99099 |
| PDX1258 | Cediranib | VEGFR/cKIT | RTK | 4.7159 | -0.5611 | 0.0744 | 0.0681 | 4.9799 | 5.5703 | 0.99375 |
| HCC38 | Cabozantinib | VEGFR2/MET | RTK | 8.2108 | 0.3009 | 0.0376 | 0.0168 | 4.3352 | 8.1748 | 0.98657 |
| HCC1937 | Cabozantinib | VEGFR2/MET | RTK | 14.4371 | 0.7602 | 0.0053 | 0.0067 | 4.9892 | 11.0339 | 0.95897 |
| PDX1258 | Cabozantinib | VEGFR2/MET | RTK | 8.2309 | 0.2796 | 0.0244 | 0.0160 | 3.8695 | 8.9263 | 0.98303 |
| MDA-MB-436 | Cabozantinib | VEGFR2/MET | RTK | 6.5187 | 0.0862 | 0.0592 | 0.0149 | 2.1788 | 10.7014 | 0.98785 |
| MCF7 | Cabozantinib | VEGFR2/MET | RTK | 4.8819 | -0.0993 | 0.1069 | 0.0302 | 1.8080 | 8.9638 | 0.99698 |
| HCC1500 | Cabozantinib | VEGFR2/MET | RTK | 4.6683 | 0.1837 | 0.0599 | 0.0128 | 4.9992 | 4.2912 | 0.97044 |
| HCC1954 | Cabozantinib | VEGFR2/MET | RTK | 10.9106 | 0.6390 | -0.0135 | -0.0074 | 5.0000 | 13.0234 | 0.87916 |
| CAL-51 | Cabozantinib | VEGFR2/MET | RTK | 7.7705 | 0.3063 | 0.0598 | 0.0166 | 1.8325 | 14.1514 | 0.98918 |
| MCF 10A | Cabozantinib | VEGFR2/MET | RTK | 25.9104 | 0.8434 | -0.0114 | 0.0040 | 4.9998 | 11.7694 | 0.81226 |
| SK-BR-3 | Cabozantinib | VEGFR2/MET | RTK | 9.7073 | 0.4422 | 0.0013 | 0.0011 | 5.0000 | 12.0523 | 0.95604 |
| HCC1395 | Cabozantinib | VEGFR2/MET | RTK | 5.5518 | 0.1138 | 0.0722 | 0.0131 | 1.6522 | 9.2961 | 0.98977 |
| HCC70 | Cabozantinib | VEGFR2/MET | RTK | 1.5024 | -0.0911 | 0.2658 | 0.0226 | 0.5892 | 9.6961 | 0.92355 |
| MDA-MB-231 | Cabozantinib | VEGFR2/MET | RTK | 4.8325 | 0.0749 | 0.1413 | 0.0336 | 1.2384 | 11.7338 | 0.95871 |
| MDA-MB-134-VI | Cabozantinib | VEGFR2/MET | RTK | 10.9194 | 0.6362 | -0.0167 | -0.0063 | 5.0000 | 12.725 | 0.88168 |
| MDA-MB-157 | Cabozantinib | VEGFR2/MET | RTK | 2.7778 | 0.1490 | 0.2101 | 0.0326 | 0.5335 | 21.7804 | 0.97157 |