Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-468 | Taxol | Chemo | Chemotherapy | 0.001354 | -0.5218 | 1.0076 | 0.5243 | 1.2795 | 0.0023644 | 0.95471 |
| Hs 578T | Taxol | Chemo | Chemotherapy | 0.0010154 | -0.3752 | 0.9535 | 0.4788 | 1.2811 | 0.0015458 | 0.95438 |
| Hs 578T | Topotecan | Topo I | Chemotherapy | 0.0049855 | -0.4488 | 1.0175 | 0.4717 | 1.1814 | 0.0076404 | 0.9429 |
| MDA-MB-468 | Topotecan | Topo I | Chemotherapy | 0.015779 | -0.6577 | 1.0692 | 0.4464 | 2.1036 | 0.023029 | 0.99528 |
| BT-20 | Taxol | Chemo | Chemotherapy | 0.0020158 | -0.5760 | 0.9854 | 0.4456 | 2.0677 | 0.0028795 | 0.99355 |
| MDA-MB-361 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0017737 | -0.9902 | 1.4103 | 0.4329 | 0.6207 | 0.010237 | 0.9975 |
| SUM149PT | Topotecan | Topo I | Chemotherapy | 0.0056894 | -0.4596 | 0.9408 | 0.4257 | 1.0455 | 0.0084398 | 0.94 |
| HCC1954 | Taxol | Chemo | Chemotherapy | 0.0024667 | -0.3961 | 0.8347 | 0.4142 | 1.6514 | 0.0034177 | 0.98666 |
| Hs 578T | AZD7762 | CHK1/2 | Cell cycle | 0.015096 | -0.5983 | 0.8646 | 0.4133 | 1.8783 | 0.01967 | 0.95944 |
| MDA-MB-468 | Volasertib | PLK | Cell cycle | 0.002104 | -0.4485 | 0.9279 | 0.3934 | 2.9173 | 0.0026072 | 0.99938 |
| PDXHCI002 | Volasertib | PLK | Cell cycle | 0.0037003 | -0.5892 | 0.8480 | 0.3925 | 4.6276 | 0.0042869 | 0.99531 |
| HCC1806 | AZD7762 | CHK1/2 | Cell cycle | 0.016629 | -0.4822 | 0.8897 | 0.3907 | 1.6771 | 0.023183 | 0.99277 |
| HCC38 | Topotecan | Topo I | Chemotherapy | 0.0068073 | -0.5041 | 1.0724 | 0.3904 | 1.2181 | 0.011735 | 0.99338 |
| PDXHCI002 | Taxol | Chemo | Chemotherapy | 0.0024935 | -0.5117 | 0.9207 | 0.3881 | 2.7479 | 0.0031656 | 0.99139 |
| SUM149PT | Taxol | Chemo | Chemotherapy | 0.0015927 | -0.2583 | 0.8405 | 0.3816 | 3.1045 | 0.0017914 | 0.99574 |
| BT-20 | Topotecan | Topo I | Chemotherapy | 0.012333 | -0.6410 | 1.0284 | 0.3794 | 0.9448 | 0.029071 | 0.99592 |
| HCC1954 | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0070107 | -0.3632 | 0.9490 | 0.3748 | 1.0954 | 0.010784 | 0.99379 |
| HCC70 | Taxol | Chemo | Chemotherapy | 0.0013411 | -0.5065 | 0.9773 | 0.3742 | 1.1642 | 0.0024269 | 0.99734 |
| HCC1500 | ABT-737 | Bcl2/XL | Misc | 0.0085142 | -0.7359 | 1.1288 | 0.3716 | 0.9283 | 0.022222 | 0.99554 |
| SK-BR-3 | Taxol | Chemo | Chemotherapy | 0.0019068 | -0.3401 | 0.8905 | 0.3665 | 2.3888 | 0.0023578 | 0.96349 |
| SUM149PT | Dinaciclib | pan CDK | Cell cycle | 0.013311 | -0.5676 | 0.6891 | 0.3611 | 4.0226 | 0.016068 | 0.99946 |
| HCC1954 | Topotecan | Topo I | Chemotherapy | 0.011912 | -0.4011 | 0.8695 | 0.3601 | 0.7510 | 0.02452 | 0.96722 |
| SUM149PT | Luminespib | HSP90 | Misc | 0.005116 | -0.3912 | 0.7555 | 0.3563 | 2.6742 | 0.0063272 | 0.99952 |
| CAMA-1 | Taxol | Chemo | Chemotherapy | 0.0022699 | -0.4944 | 0.9525 | 0.3547 | 2.4920 | 0.0029769 | 0.99478 |
| HCC1806 | Topotecan | Topo I | Chemotherapy | 0.0052709 | -0.5458 | 1.0747 | 0.3515 | 1.0834 | 0.0094879 | 0.95633 |