Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0454 0.21959
MCF7 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.0450 0.30684
MCF7 PF-4708671
0.001
p70S6K
PI3K/mTOR
 0.9795 0.00171
MCF7 PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0439 -0.00212
MCF7 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0805 0.00096
MCF7 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0248 0.00044
MCF7 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0199 0.00010
MCF7 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9690 0.00156
MCF7 PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.8834 0.00119
MCF7 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.7716 0.00511
MCF7 PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.5577 0.02750
MCF7 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0368 0.00027
MCF7 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9620 0.00263
MCF7 Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9960 0.00292
MCF7 Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.8319 0.00895
MCF7 Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.6029 0.03166
MCF7 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.4278 0.05323
MCF7 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 -0.0211 0.23629
MCF7 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2116 0.31687
MCF7 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.2690 0.39298
MCF7 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9779 0.00232
MCF7 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9402 0.00205
MCF7 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.8902 0.00590
MCF7 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.7079 0.01611
MCF7 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.5184 0.03401