Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9564 0.00563
MCF7 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9150 0.00711
MCF7 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.8805 0.00944
MCF7 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.5638 0.02943
MCF7 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.2670 0.08111
MCF7 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.1371 0.15648
MCF7 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.0173 0.25362
MCF7 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.0138 0.27802
MCF7 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.1330 0.33021
MCF7 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.5265 0.02664
MCF7 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.4927 0.02583
MCF7 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.4748 0.02949
MCF7 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.4572 0.03267
MCF7 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.4265 0.03012
MCF7 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.3694 0.04146
MCF7 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.4158 0.03953
MCF7 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.3925 0.03514
MCF7 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.3865 0.04594
MCF7 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9456 0.00258
MCF7 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.7582 0.01817
MCF7 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.4849 0.03793
MCF7 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.2012 0.09873
MCF7 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.1240 0.14922
MCF7 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.0768 0.17851
MCF7 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.0526 0.20095