Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT Ipatasertib
0.001
AKT
PI3K/mTOR
 0.9939 -0.00030
SUM159PT Ipatasertib
0.0031623
AKT
PI3K/mTOR
 0.9915 0.00209
SUM159PT Ipatasertib
0.01
AKT
PI3K/mTOR
 0.9969 0.00237
SUM159PT Ipatasertib
0.031623
AKT
PI3K/mTOR
 0.9895 -0.00105
SUM159PT Ipatasertib
0.1
AKT
PI3K/mTOR
 0.9730 -0.00168
SUM159PT Ipatasertib
0.31623
AKT
PI3K/mTOR
 0.9326 -0.00268
SUM159PT Ipatasertib
1.0
AKT
PI3K/mTOR
 0.7983 -0.00067
SUM159PT Ipatasertib
3.1623
AKT
PI3K/mTOR
 0.6578 0.00804
SUM159PT Ipatasertib
10.0
AKT
PI3K/mTOR
 0.4884 0.01156
SUM159PT Alpelisib
0.001
PI3Ka
PI3K/mTOR
 1.0014 0.00156
SUM159PT Alpelisib
0.0031623
PI3Ka
PI3K/mTOR
 1.0024 0.00301
SUM159PT Alpelisib
0.01
PI3Ka
PI3K/mTOR
 1.0145 -0.00101
SUM159PT Alpelisib
0.031623
PI3Ka
PI3K/mTOR
 0.9978 -0.00090
SUM159PT Alpelisib
0.1
PI3Ka
PI3K/mTOR
 0.9667 -0.00329
SUM159PT Alpelisib
0.31623
PI3Ka
PI3K/mTOR
 0.8905 -0.00392
SUM159PT Alpelisib
1.0
PI3Ka
PI3K/mTOR
 0.7778 -0.00335
SUM159PT Alpelisib
3.1623
PI3Ka
PI3K/mTOR
 0.5814 0.00126
SUM159PT Alpelisib
10.0
PI3Ka
PI3K/mTOR
 0.2818 0.00949
SUM159PT Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 0.9876 -0.00563
SUM159PT Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 0.9225 -0.00410
SUM159PT Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.7205 -0.00585
SUM159PT Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.4157 -0.00322
SUM159PT Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.2698 0.00034
SUM159PT Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.1762 0.00443
SUM159PT Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.1614 0.00770