Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM159PT Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.1075 0.01095
SUM159PT Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 0.0916 0.01618
SUM159PT TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0102 -0.00100
SUM159PT TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0195 -0.00145
SUM159PT TGX221
0.01
PI3Kb
PI3K/mTOR
 0.9954 0.00085
SUM159PT TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0121 -0.00201
SUM159PT TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0189 0.00044
SUM159PT TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.0173 0.00129
SUM159PT TGX221
1.0
PI3Kb
PI3K/mTOR
 1.0038 0.00704
SUM159PT TGX221
3.1623
PI3Kb
PI3K/mTOR
 1.0028 -0.00028
SUM159PT TGX221
10.0
PI3Kb
PI3K/mTOR
 0.9906 -0.00611
SUM159PT Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 0.9991 0.00108
SUM159PT Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9975 -0.00235
SUM159PT Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9950 -0.00174
SUM159PT Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9152 -0.00371
SUM159PT Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.5906 -0.00259
SUM159PT Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.3139 0.00336
SUM159PT Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.1811 0.01117
SUM159PT Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.1446 0.01163
SUM159PT Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 0.1057 0.02793
SUM159PT Everolimus
0.001
mTOR1
PI3K/mTOR
 0.7206 -0.00118
SUM159PT Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.7375 -0.00199
SUM159PT Everolimus
0.01
mTOR1
PI3K/mTOR
 0.6769 -0.00242
SUM159PT Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.7013 -0.00351
SUM159PT Everolimus
0.1
mTOR1
PI3K/mTOR
 0.6415 0.00177