Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM1315MO2 Ipatasertib
1.0
AKT
PI3K/mTOR
 0.8213 0.01550
SUM1315MO2 Ipatasertib
3.1623
AKT
PI3K/mTOR
 0.8012 0.00939
SUM1315MO2 Ipatasertib
10.0
AKT
PI3K/mTOR
 0.6070 0.03303
SUM1315MO2 Alpelisib
0.001
PI3Ka
PI3K/mTOR
 1.0475 0.00824
SUM1315MO2 Alpelisib
0.0031623
PI3Ka
PI3K/mTOR
 1.0318 0.00246
SUM1315MO2 Alpelisib
0.01
PI3Ka
PI3K/mTOR
 1.0614 0.00507
SUM1315MO2 Alpelisib
0.031623
PI3Ka
PI3K/mTOR
 1.0449 0.00027
SUM1315MO2 Alpelisib
0.1
PI3Ka
PI3K/mTOR
 0.9297 0.01727
SUM1315MO2 Alpelisib
0.31623
PI3Ka
PI3K/mTOR
 0.8029 0.01546
SUM1315MO2 Alpelisib
1.0
PI3Ka
PI3K/mTOR
 0.8085 0.01255
SUM1315MO2 Alpelisib
3.1623
PI3Ka
PI3K/mTOR
 0.6819 0.03591
SUM1315MO2 Alpelisib
10.0
PI3Ka
PI3K/mTOR
 0.3829 0.08538
SUM1315MO2 Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 0.9226 0.01266
SUM1315MO2 Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 0.8267 0.01142
SUM1315MO2 Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.8108 0.02764
SUM1315MO2 Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.7455 0.03366
SUM1315MO2 Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.6418 0.04302
SUM1315MO2 Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.5587 0.04057
SUM1315MO2 Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.4376 0.05814
SUM1315MO2 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.2949 0.07699
SUM1315MO2 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 0.0942 0.12395
SUM1315MO2 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0439 0.00081
SUM1315MO2 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 0.9766 -0.00487
SUM1315MO2 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0197 0.00317
SUM1315MO2 TGX221
0.031623
PI3Kb
PI3K/mTOR
 0.8514 0.00805