Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM1315MO2 TGX221
0.1
PI3Kb
PI3K/mTOR
 0.8997 0.00543
SUM1315MO2 TGX221
0.31623
PI3Kb
PI3K/mTOR
 0.7417 0.01613
SUM1315MO2 TGX221
1.0
PI3Kb
PI3K/mTOR
 0.8274 0.00763
SUM1315MO2 TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.7054 0.01248
SUM1315MO2 TGX221
10.0
PI3Kb
PI3K/mTOR
 0.7329 0.01665
SUM1315MO2 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0120 0.01157
SUM1315MO2 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9535 0.00653
SUM1315MO2 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.8860 -0.00393
SUM1315MO2 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.7825 0.01210
SUM1315MO2 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.5394 0.03199
SUM1315MO2 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.3576 0.05314
SUM1315MO2 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.1650 0.11152
SUM1315MO2 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.0353 0.14973
SUM1315MO2 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.0903 0.18629
SUM1315MO2 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.6072 0.03071
SUM1315MO2 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.5889 0.03189
SUM1315MO2 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.5329 0.02984
SUM1315MO2 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.5377 0.03043
SUM1315MO2 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.6021 0.02394
SUM1315MO2 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.5248 0.03045
SUM1315MO2 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.5032 0.03850
SUM1315MO2 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.5752 0.02144
SUM1315MO2 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.4018 0.05943
SUM1315MO2 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9135 0.00589
SUM1315MO2 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.8467 0.00370