Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| T47D | Cabozantinib | 0.1 | VEGFR2/MET | RTK | 1.0173 | -0.00368 |
| T47D | Cabozantinib | 0.31623 | VEGFR2/MET | RTK | 1.0001 | -0.00020 |
| T47D | Cabozantinib | 1.0 | VEGFR2/MET | RTK | 0.9575 | -0.00074 |
| T47D | Cabozantinib | 3.1623 | VEGFR2/MET | RTK | 0.8951 | 0.00602 |
| T47D | Cabozantinib | 10.0 | VEGFR2/MET | RTK | 0.3126 | 0.03378 |
| CAMA-1 | Abemaciclib | 0.001 | CDK4/6 | Cell cycle | 0.8607 | -0.00387 |
| CAMA-1 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.7616 | -0.01500 |
| CAMA-1 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.4456 | -0.00670 |
| CAMA-1 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.2699 | -0.00638 |
| CAMA-1 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.2405 | 0.00132 |
| CAMA-1 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.2781 | -0.00716 |
| CAMA-1 | Abemaciclib | 1.0 | CDK4/6 | Cell cycle | 0.2755 | -0.00154 |
| CAMA-1 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.2833 | -0.00928 |
| CAMA-1 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | 0.2222 | 0.01287 |
| CAMA-1 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 0.9283 | -0.00091 |
| CAMA-1 | Palbociclib | 0.001 | CDK4/6 | Cell cycle | 1.0065 | 0.00159 |
| CAMA-1 | Palbociclib | 0.0031623 | CDK4/6 | Cell cycle | 0.9617 | -0.00471 |
| CAMA-1 | Palbociclib | 0.01 | CDK4/6 | Cell cycle | 0.8770 | -0.00482 |
| CAMA-1 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.6754 | -0.00682 |
| CAMA-1 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.4632 | -0.00245 |
| CAMA-1 | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.2950 | 0.00058 |
| CAMA-1 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.2926 | 0.00268 |
| CAMA-1 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.2816 | 0.00067 |
| CAMA-1 | AZD7762 | 0.001 | CHK1/2 | Cell cycle | 1.0010 | 0.00104 |
| CAMA-1 | AZD7762 | 0.0031623 | CHK1/2 | Cell cycle | 1.0273 | -0.00132 |