Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Alpelisib
10.0
PI3Ka
PI3K/mTOR
 0.5787 -0.00396
MCF 10A Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 0.9428 -0.00201
MCF 10A Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 0.8765 -0.00453
MCF 10A Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.7784 -0.00578
MCF 10A Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.6432 -0.00634
MCF 10A Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.5033 -0.00658
MCF 10A Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.3928 -0.00456
MCF 10A Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.2514 -0.00089
MCF 10A Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.1784 0.00574
MCF 10A Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 0.0593 0.02350
MCF 10A TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0047 0.00138
MCF 10A TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0092 0.00030
MCF 10A TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0082 0.00000
MCF 10A TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0056 -0.00158
MCF 10A TGX221
0.1
PI3Kb
PI3K/mTOR
 0.9925 -0.00084
MCF 10A TGX221
0.31623
PI3Kb
PI3K/mTOR
 0.9933 0.00014
MCF 10A TGX221
1.0
PI3Kb
PI3K/mTOR
 0.9857 -0.00034
MCF 10A TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.9877 0.00099
MCF 10A TGX221
10.0
PI3Kb
PI3K/mTOR
 0.9505 0.00287
MCF 10A Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0023 -0.00057
MCF 10A Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9969 -0.00072
MCF 10A Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9994 -0.00083
MCF 10A Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9695 -0.00087
MCF 10A Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.8107 -0.00393
MCF 10A Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.4931 -0.00524