Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.2678 -0.00196
MCF 10A Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.2035 -0.00178
MCF 10A Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 0.1275 0.02573
MCF 10A Everolimus
0.001
mTOR1
PI3K/mTOR
 0.9892 0.00336
MCF 10A Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.9656 0.00135
MCF 10A Everolimus
0.01
mTOR1
PI3K/mTOR
 0.9345 0.00151
MCF 10A Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.9001 0.00146
MCF 10A Everolimus
0.1
mTOR1
PI3K/mTOR
 0.8695 0.00030
MCF 10A Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.8655 -0.00126
MCF 10A Everolimus
1.0
mTOR1
PI3K/mTOR
 0.8499 -0.00293
MCF 10A Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.8217 -0.00209
MCF 10A Everolimus
10.0
mTOR1
PI3K/mTOR
 0.7889 -0.00213
MCF 10A INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9954 -0.00126
MCF 10A INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9792 -0.00139
MCF 10A INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.9153 -0.00426
MCF 10A INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.7371 -0.00404
MCF 10A INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.4329 -0.00517
MCF 10A INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.2441 -0.00140
MCF 10A INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.1909 -0.00146
MCF 10A INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.1783 -0.00298
MCF 10A INK-128
3.1623
mTORC1/2
PI3K/mTOR
 0.1716 -0.00275
MCF 10A PF-4708671
0.001
p70S6K
PI3K/mTOR
 1.0109 -0.00004
MCF 10A PF-4708671
0.0031623
p70S6K
PI3K/mTOR
 1.0103 0.00046
MCF 10A PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.0037 -0.00088
MCF 10A PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0094 0.00008