Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A PF-4708671
0.1
p70S6K
PI3K/mTOR
 0.9978 -0.00086
MCF 10A PF-4708671
0.31623
p70S6K
PI3K/mTOR
 0.9699 -0.00293
MCF 10A PF-4708671
1.0
p70S6K
PI3K/mTOR
 0.9275 -0.00422
MCF 10A PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.8358 -0.00533
MCF 10A PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.7207 -0.00445
MCF 10A Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0041 0.00156
MCF 10A Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0004 -0.00065
MCF 10A Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9879 -0.00093
MCF 10A Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.9743 -0.00203
MCF 10A Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.9318 -0.00464
MCF 10A Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.8783 -0.00478
MCF 10A Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.7119 -0.00237
MCF 10A Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 0.0988 0.10554
MCF 10A Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.1604 0.30799
MCF 10A Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9898 0.00060
MCF 10A Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9858 -0.00280
MCF 10A Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9386 -0.00321
MCF 10A Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.7782 0.01075
MCF 10A Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.8447 -0.00592
MCF 10A Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.7565 -0.00695
MCF 10A Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.5962 -0.00747
MCF 10A Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.4105 -0.00468
MCF 10A Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.1934 -0.00324
MCF 10A Ceritinib
0.001
ALK
RTK
 1.0043 0.00110
MCF 10A Ceritinib
0.0031623
ALK
RTK
 1.0028 -0.00071