Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9871 -0.00262
Hs 578T Buparlisib
0.01
pan PI3K
PI3K/mTOR
 0.9506 -0.00209
Hs 578T Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 0.9945 0.00653
Hs 578T Buparlisib
0.1
pan PI3K
PI3K/mTOR
 0.8834 0.00912
Hs 578T Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.7649 0.01047
Hs 578T Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.3668 0.13381
Hs 578T Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2720 0.56181
Hs 578T Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.3434 0.64760
Hs 578T Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9054 0.00518
Hs 578T Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.8929 -0.00092
Hs 578T Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9082 0.00005
Hs 578T Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.8240 0.01354
Hs 578T Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.8043 0.01319
Hs 578T Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.7398 0.01122
Hs 578T Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.5305 0.05583
Hs 578T Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.3434 0.09268
Hs 578T Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.0345 0.24812
Hs 578T Ceritinib
0.001
ALK
RTK
 1.0232 -0.00404
Hs 578T Ceritinib
0.0031623
ALK
RTK
 0.9793 -0.00267
Hs 578T Ceritinib
0.01
ALK
RTK
 1.0252 0.00103
Hs 578T Ceritinib
0.031623
ALK
RTK
 0.9788 0.00494
Hs 578T Ceritinib
0.1
ALK
RTK
 0.9622 0.01408
Hs 578T Ceritinib
0.31623
ALK
RTK
 0.8074 0.04877
Hs 578T Ceritinib
1.0
ALK
RTK
 0.3515 0.17148
Hs 578T Ceritinib
3.1623
ALK
RTK
 0.1599 0.22058