Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.6222 0.04133
Hs 578T Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.3930 0.09481
Hs 578T Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.2467 0.13162
Hs 578T Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.0179 0.33693
Hs 578T TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0290 0.00147
Hs 578T TGX221
0.0031623
PI3Kb
PI3K/mTOR
 0.9868 0.00622
Hs 578T TGX221
0.01
PI3Kb
PI3K/mTOR
 0.9550 0.00661
Hs 578T TGX221
0.031623
PI3Kb
PI3K/mTOR
 0.9501 0.00501
Hs 578T TGX221
0.1
PI3Kb
PI3K/mTOR
 0.9809 0.00353
Hs 578T TGX221
0.31623
PI3Kb
PI3K/mTOR
 0.9410 0.00460
Hs 578T TGX221
1.0
PI3Kb
PI3K/mTOR
 0.9413 0.01108
Hs 578T TGX221
3.1623
PI3Kb
PI3K/mTOR
 0.8410 0.01441
Hs 578T TGX221
10.0
PI3Kb
PI3K/mTOR
 0.7094 0.03977
Hs 578T Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0888 0.00475
Hs 578T Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9607 0.00174
Hs 578T Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.8216 -0.00132
Hs 578T Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.6830 0.01100
Hs 578T Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.3509 0.05427
Hs 578T Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.1934 0.10745
Hs 578T Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.0611 0.21334
Hs 578T Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 -0.0338 0.30757
Hs 578T Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.2174 0.53645
Hs 578T Everolimus
0.001
mTOR1
PI3K/mTOR
 0.5538 0.03206
Hs 578T Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.5115 0.02275
Hs 578T Everolimus
0.01
mTOR1
PI3K/mTOR
 0.4819 0.03030