Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HCC1806 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.1855 0.49892
HCC1806 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.2692 0.52421
HCC1806 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 0.9358 -0.00015
HCC1806 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 0.9749 0.00556
HCC1806 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 1.0206 -0.00005
HCC1806 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.9723 0.00018
HCC1806 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.9245 0.00712
HCC1806 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.8997 0.00862
HCC1806 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.9419 0.01472
HCC1806 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.7587 0.01597
HCC1806 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 0.1936 0.14595
HCC1806 Ceritinib
0.001
ALK
RTK
 1.0121 0.00605
HCC1806 Ceritinib
0.0031623
ALK
RTK
 1.0658 -0.00214
HCC1806 Ceritinib
0.01
ALK
RTK
 1.0487 0.00015
HCC1806 Ceritinib
0.031623
ALK
RTK
 1.0774 -0.00516
HCC1806 Ceritinib
0.1
ALK
RTK
 1.0986 -0.00400
HCC1806 Ceritinib
0.31623
ALK
RTK
 1.1237 -0.00775
HCC1806 Ceritinib
1.0
ALK
RTK
 0.8590 0.02331
HCC1806 Ceritinib
3.1623
ALK
RTK
 0.1763 0.12321
HCC1806 Ceritinib
10.0
ALK
RTK
 -0.4060 0.58043
HCC1806 Neratinib
0.00031623
EGFR/HER2
RTK
 1.0684 0.00476
HCC1806 Neratinib
0.001
EGFR/HER2
RTK
 1.0533 -0.00088
HCC1806 Neratinib
0.0031623
EGFR/HER2
RTK
 1.0102 0.00509
HCC1806 Neratinib
0.01
EGFR/HER2
RTK
 0.9959 0.01677
HCC1806 Neratinib
0.031623
EGFR/HER2
RTK
 0.8990 0.02920