Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
Hs 578T Dasatinib
0.1
BCR/ABL
MAPK/nRTK
 0.1767 0.22807
Hs 578T Dasatinib
0.31623
BCR/ABL
MAPK/nRTK
 -0.0741 0.44684
Hs 578T Dasatinib
1.0
BCR/ABL
MAPK/nRTK
 -0.1708 0.52693
Hs 578T Dasatinib
3.1623
BCR/ABL
MAPK/nRTK
 -0.2270 0.58927
Hs 578T Dasatinib
10.0
BCR/ABL
MAPK/nRTK
 -0.2442 0.58022
Hs 578T Trametinib
0.0001
MEK
MAPK/nRTK
 0.9824 -0.00001
Hs 578T Trametinib
0.00031623
MEK
MAPK/nRTK
 0.8765 0.01406
Hs 578T Trametinib
0.001
MEK
MAPK/nRTK
 0.8052 0.01533
Hs 578T Trametinib
0.0031623
MEK
MAPK/nRTK
 0.6579 0.03630
Hs 578T Trametinib
0.01
MEK
MAPK/nRTK
 0.4273 0.05451
Hs 578T Trametinib
0.031623
MEK
MAPK/nRTK
 0.2528 0.11280
Hs 578T Trametinib
0.1
MEK
MAPK/nRTK
 0.2567 0.12703
Hs 578T Trametinib
0.31623
MEK
MAPK/nRTK
 0.1931 0.13691
Hs 578T Trametinib
1.0
MEK
MAPK/nRTK
 0.2278 0.14455
Hs 578T Saracatinib
0.001
SRC
MAPK/nRTK
 1.0591 -0.00629
Hs 578T Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9985 0.00293
Hs 578T Saracatinib
0.01
SRC
MAPK/nRTK
 1.0002 0.00528
Hs 578T Saracatinib
0.031623
SRC
MAPK/nRTK
 0.9337 -0.00789
Hs 578T Saracatinib
0.1
SRC
MAPK/nRTK
 0.9009 -0.00001
Hs 578T Saracatinib
0.31623
SRC
MAPK/nRTK
 0.8642 0.00139
Hs 578T Saracatinib
1.0
SRC
MAPK/nRTK
 0.7797 0.01214
Hs 578T Saracatinib
3.1623
SRC
MAPK/nRTK
 0.6283 0.02597
Hs 578T Saracatinib
10.0
SRC
MAPK/nRTK
 0.1890 0.22844
Hs 578T ABT-737
0.001
Bcl2/XL
Misc
 1.0248 -0.00184
Hs 578T ABT-737
0.0031623
Bcl2/XL
Misc
 1.0074 0.00379