Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF 10A Dinaciclib
0.001
pan CDK
Cell cycle
 1.0227 0.00085
MCF 10A Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.0470 0.00559
MCF 10A Dinaciclib
0.01
pan CDK
Cell cycle
 0.9375 0.00780
MCF 10A Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.1784 0.47267
MCF 10A Dinaciclib
0.1
pan CDK
Cell cycle
 -0.2281 0.56292
MCF 10A Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.2300 0.54464
MCF 10A Dinaciclib
1.0
pan CDK
Cell cycle
 -0.2250 0.51384
MCF 10A Cisplatin
0.0010833
Chemo
Chemotherapy
 1.0095 0.00219
MCF 10A Cisplatin
0.0033333
Chemo
Chemotherapy
 1.0283 -0.00293
MCF 10A Cisplatin
0.01
Chemo
Chemotherapy
 1.0179 -0.00243
MCF 10A Cisplatin
0.031667
Chemo
Chemotherapy
 1.0107 0.00080
MCF 10A Cisplatin
0.1
Chemo
Chemotherapy
 1.0172 0.00173
MCF 10A Cisplatin
0.31623
Chemo
Chemotherapy
 0.9707 0.00526
MCF 10A Cisplatin
1.0
Chemo
Chemotherapy
 0.9204 0.01414
MCF 10A Cisplatin
3.1623
Chemo
Chemotherapy
 0.5871 0.04822
MCF 10A Cisplatin
10.0
Chemo
Chemotherapy
 0.3794 0.06669
MCF 10A Doxorubicin
0.00031623
Chemo
Chemotherapy
 0.9818 0.00026
MCF 10A Doxorubicin
0.001
Chemo
Chemotherapy
 0.9684 -0.00244
MCF 10A Doxorubicin
0.0031623
Chemo
Chemotherapy
 0.8581 -0.00399
MCF 10A Doxorubicin
0.01
Chemo
Chemotherapy
 0.5513 0.02169
MCF 10A Doxorubicin
0.031623
Chemo
Chemotherapy
 0.0697 0.06851
MCF 10A Doxorubicin
0.1
Chemo
Chemotherapy
 -0.0073 0.03194
MCF 10A Doxorubicin
0.31623
Chemo
Chemotherapy
 0.0007 0.02703
MCF 10A Doxorubicin
1.0
Chemo
Chemotherapy
 -0.0087 0.04139
MCF 10A Doxorubicin
3.1623
Chemo
Chemotherapy
 -0.3242 0.76439