Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 2 1993 327 0.1048 0.0981 0.1641 0.1764
A-375 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 3 1365 274 0.0686 0.0981 0.2007 0.1764
A-375 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 1 1467 302 0.0733 0.0654 0.2059 0.2273
A-375 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 1435 332 0.0694 0.0654 0.2314 0.2273
A-375 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 1124 275 0.0534 0.0654 0.2447 0.2273
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 19613 936 1.0160 1.0000 0.0477 0.0485
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 19375 946 1.0025 1.0000 0.0488 0.0485
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 18973 930 0.9815 1.0000 0.0490 0.0485
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 15518 861 0.7973 0.8926 0.0555 0.0523
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 18224 910 0.9418 0.8926 0.0499 0.0523
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 18188 934 0.9386 0.8926 0.0514 0.0523
A-375 Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 1 9095 519 0.4665 0.4696 0.0571 0.0532
A-375 Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 2 9759 545 0.5012 0.4696 0.0558 0.0532
A-375 Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 3 8504 397 0.4410 0.4696 0.0467 0.0532
A-375 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 1622 180 0.0784 0.0695 0.1110 0.1086
A-375 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 2 1440 149 0.0702 0.0695 0.1035 0.1086
A-375 Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 3 1239 138 0.0599 0.0695 0.1114 0.1086
A-375 Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 8355 177 0.4449 0.4213 0.0212 0.0200
A-375 Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 7861 159 0.4190 0.4213 0.0202 0.0200
A-375 Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 7493 140 0.4000 0.4213 0.0187 0.0200
A-375 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 6033 99 0.3228 0.3515 0.0164 0.0163
A-375 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 2 6975 120 0.3729 0.3515 0.0172 0.0163
A-375 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 3 6696 102 0.3587 0.3515 0.0152 0.0163
A-375 Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 1 6672 165 0.3540 0.3018 0.0247 0.0284
A-375 Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 2 6509 181 0.3442 0.3018 0.0278 0.0284