Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 1 2955 377 0.3061 0.3267 0.1276 0.1321
COLO 858 Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 2 3197 423 0.3293 0.3267 0.1323 0.1321
COLO 858 Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 3362 459 0.3447 0.3267 0.1365 0.1321
COLO 858 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 1 2189 432 0.2086 0.2262 0.1974 0.1950
COLO 858 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 2 2428 436 0.2365 0.2262 0.1796 0.1950
COLO 858 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 3 2483 517 0.2334 0.2262 0.2082 0.1950
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 1382 879 0.0597 0.0598 0.6360 0.6178
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 1411 883 0.0627 0.0598 0.6258 0.6178
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1178 697 0.0571 0.0598 0.5917 0.6178
COLO 858 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 1 2594 352 0.2662 0.2820 0.1357 0.1635
COLO 858 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 2 2796 541 0.2677 0.2820 0.1935 0.1635
COLO 858 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 3134 506 0.3120 0.2820 0.1615 0.1635
COLO 858 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 2278 812 0.1741 0.1578 0.3565 0.3985
COLO 858 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2179 931 0.1482 0.1578 0.4273 0.3985
COLO 858 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 3 2164 891 0.1511 0.1578 0.4117 0.3985
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 1692 781 0.1082 0.1083 0.4616 0.4526
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 2 1784 762 0.1213 0.1083 0.4271 0.4526
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 1514 710 0.0955 0.1083 0.4690 0.4526
COLO 858 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 1 1059 843 0.0256 0.0309 0.7960 0.7785
COLO 858 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 2 1234 950 0.0337 0.0309 0.7699 0.7785
COLO 858 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 3 1219 938 0.0334 0.0309 0.7695 0.7785
COLO 858 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 2082 1092 0.1175 0.1167 0.5245 0.5321
COLO 858 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 2 1969 1061 0.1078 0.1167 0.5389 0.5321
COLO 858 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 2252 1200 0.1249 0.1167 0.5329 0.5321
COLO 858 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 1557 1149 0.0484 0.0451 0.7380 0.7585