Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 21481 1121 1.0310 1.0000 0.0522 0.0504
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 20940 1098 1.0048 1.0000 0.0524 0.0504
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 20360 1046 1.0111 1.0000 0.0514 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 19971 929 0.9642 1.0000 0.0465 0.0504
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 19884 1032 0.9869 1.0000 0.0519 0.0527
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 19613 936 1.0160 1.0000 0.0477 0.0485
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 19375 946 1.0025 1.0000 0.0488 0.0485
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 18973 930 0.9815 1.0000 0.0490 0.0485
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 18747 969 0.8520 0.8197 0.0517 0.0506
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 2 18341 936 0.8341 0.8197 0.0510 0.0506
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 2 18224 910 0.9418 0.8926 0.0499 0.0523
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 3 18188 934 0.9386 0.8926 0.0514 0.0523
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 17737 603 1.0777 1.0016 0.0340 0.0383
A-375 Vemurafenib I-BET151 0.000 0.000
uM
 72
hr
 1 17149 1786 1.1105 1.0000 0.1041 0.1052
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 1 17083 736 1.1561 1.0000 0.0431 0.0814
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 1 17029 767 1.0229 1.0000 0.0450 0.0476
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 16836 650 1.0181 1.0016 0.0386 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 16730 807 1.0016 1.0000 0.0482 0.0476
A-375 Vemurafenib I-BET 0.000 0.000
uM
 72
hr
 1 16558 1621 1.0954 1.0000 0.0979 0.1030
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 16317 808 0.9755 1.0000 0.0495 0.0476
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