Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A-375 | Vemurafenib | Dasatinib | 3.160 | 0.316 | uM | 72 | hr | 1 | 1025 | 184 | 0.0426 | 0.0433 | 0.1795 | 0.1874 |
| A-375 | Vemurafenib | Defactinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 9567 | 390 | 0.4398 | 0.4342 | 0.0408 | 0.0408 |
| A-375 | Vemurafenib | Dasatinib | 1.000 | 1.000 | uM | 72 | hr | 1 | 1021 | 134 | 0.0449 | 0.0398 | 0.1312 | 0.1218 |
| A-375 | Vemurafenib | Dasatinib | 0.316 | 0.000 | uM | 72 | hr | 1 | 5034 | 110 | 0.2493 | 0.2652 | 0.0219 | 0.0225 |
| A-375 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 22233 | 990 | 1.0180 | 1.0000 | 0.0445 | 0.0468 |
| A-375 | Vemurafenib | Defactinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 16963 | 834 | 0.7730 | 0.8197 | 0.0492 | 0.0506 |
| A-375 | Vemurafenib | Dasatinib | 0.100 | 0.000 | uM | 72 | hr | 1 | 7790 | 111 | 0.3888 | 0.4180 | 0.0142 | 0.0173 |
| A-375 | Vemurafenib | Dasatinib | 1.000 | 0.316 | uM | 72 | hr | 1 | 982 | 130 | 0.0431 | 0.0433 | 0.1324 | 0.1382 |
| A-375 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1188 | 84 | 0.0559 | 0.0490 | 0.0707 | 0.0884 |
| A-375 | Vemurafenib | Dasatinib | 3.160 | 0.000 | uM | 72 | hr | 1 | 3477 | 209 | 0.1655 | 0.1621 | 0.0601 | 0.0672 |
| A-375 | Vemurafenib | Dasatinib | 3.160 | 1.000 | uM | 72 | hr | 1 | 1265 | 271 | 0.0503 | 0.0434 | 0.2142 | 0.1958 |
| A-375 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1196 | 197 | 0.0506 | 0.0492 | 0.1647 | 0.1635 |
| A-375 | Vemurafenib | Dasatinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 3016 | 167 | 0.1443 | 0.1539 | 0.0554 | 0.0544 |
| A-375 | Vemurafenib | Dasatinib | 0.316 | 3.160 | uM | 72 | hr | 1 | 1388 | 90 | 0.0657 | 0.0636 | 0.0648 | 0.0545 |
| A-375 | Vemurafenib | Dasatinib | 0.100 | 0.316 | uM | 72 | hr | 1 | 3389 | 65 | 0.1683 | 0.1709 | 0.0192 | 0.0246 |
| A-375 | Vemurafenib | Dasatinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 5949 | 318 | 0.2851 | 0.2714 | 0.0535 | 0.0654 |
| A-375 | Vemurafenib | Dasatinib | 1.000 | 0.000 | uM | 72 | hr | 1 | 3774 | 124 | 0.1848 | 0.1953 | 0.0329 | 0.0349 |
| A-375 | Vemurafenib | Dasatinib | 0.100 | 1.000 | uM | 72 | hr | 1 | 2680 | 77 | 0.1318 | 0.1200 | 0.0287 | 0.0313 |
| A-375 | Vemurafenib | Dasatinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 4220 | 165 | 0.2053 | 0.1658 | 0.0391 | 0.0359 |
| A-375 | Vemurafenib | Dasatinib | 0.316 | 0.316 | uM | 72 | hr | 1 | 1112 | 52 | 0.0537 | 0.0545 | 0.0468 | 0.0467 |
| A-375 | Vemurafenib | Dasatinib | 0.100 | 3.160 | uM | 72 | hr | 1 | 2327 | 89 | 0.1133 | 0.0917 | 0.0382 | 0.0407 |
| A-375 | Vemurafenib | Dasatinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 19971 | 929 | 0.9642 | 1.0000 | 0.0465 | 0.0504 |
| A-375 | Vemurafenib | Dasatinib | 0.316 | 1.000 | uM | 72 | hr | 1 | 1292 | 66 | 0.0621 | 0.0577 | 0.0511 | 0.0487 |
| A-375 | Vemurafenib | Defactinib | 0.100 | 0.000 | uM | 72 | hr | 1 | 13441 | 248 | 0.6323 | 0.4565 | 0.0185 | 0.0200 |
| A-375 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 2168 | 298 | 0.0896 | 0.0889 | 0.1375 | 0.1262 |