Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 191 77 0.1154 0.1255 0.4031 0.4181
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 196 90 0.1073 0.1255 0.4592 0.4181
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 250 98 0.1539 0.1255 0.3920 0.4181
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 255 100 0.1569 0.2379 0.3922 0.3676
MMAC-SF Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 285 67 0.2141 0.2478 0.2351 0.2217
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 1 290 89 0.2035 0.2184 0.3069 0.3304
MMAC-SF Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 2 296 50 0.2416 0.2619 0.1689 0.2293
MMAC-SF Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 3 309 93 0.2121 0.3656 0.3010 0.2907
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 319 126 0.1954 0.2184 0.3950 0.3304
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 324 106 0.2207 0.2531 0.3272 0.3208
MMAC-SF Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 333 119 0.2167 0.3044 0.3574 0.3533
MMAC-SF Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 1 337 88 0.2445 0.2619 0.2611 0.2293
MMAC-SF Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 338 89 0.2445 0.2478 0.2633 0.2217
MMAC-SF Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 342 114 0.2308 0.2379 0.3333 0.3676
MMAC-SF Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 3 345 95 0.1995 0.3311 0.2754 0.2885
MMAC-SF Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 1 348 58 0.2848 0.2478 0.1667 0.2217
MMAC-SF Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 356 103 0.2562 0.2184 0.2893 0.3304
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 366 188 0.1802 0.2143 0.5137 0.4559
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 2 367 115 0.2551 0.2531 0.3134 0.3208
MMAC-SF Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 368 66 0.3058 0.4404 0.1793 0.1902
MMAC-SF Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 376 115 0.2082 0.2628 0.3059 0.2739
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 377 155 0.1368 0.1471 0.4111 0.4142
MZ7-mel Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 378 104 0.0869 0.1027 0.2751 0.2808
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 395 154 0.2440 0.2143 0.3899 0.4559
MMAC-SF Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 403 187 0.2187 0.2143 0.4640 0.4559
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